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Tex2 Gene Detail
Summary
  • Symbol
    Tex2
  • Name
    testis expressed gene 2
  • Synonyms
    4930568E07Rik, Def-5, mKIAA1738, Taz4
  • Feature Type
    protein coding gene
  • IDs
    MGI:102465
    NCBI Gene: 21763
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:106392973-106504249 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 69.46 cM, cytoband D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3179 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102465
 protein coding gene Chr11:106392965-106504259 (-)
129S1/SvImJ ENSMUSG00200030408
 protein coding gene Chr11:103700277-103766773 (-)
A/J ENSMUSG00195018472
 protein coding gene Chr11:103399220-103465725 (-)
AKR/J ENSMUSG00220029617
 protein coding gene Chr11:103612303-103678812 (-)
BALB/cJ ENSMUSG00180016499
 protein coding gene Chr11:103721576-103788091 (-)
C3H/HeJ ENSMUSG00175011503
 protein coding gene Chr11:103670633-103737144 (-)
C57BL/6NJ ENSMUSG00215010395
 protein coding gene Chr11:103238627-103305120 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017325
 protein coding gene Chr11:102405533-102515027 (-)
CAST/EiJ ENSTCUG00005039252
 protein coding gene Chr11:103139100-103206934 (-)
CBA/J ENSMUSG00210013373
 protein coding gene Chr11:103379815-103446067 (-)
DBA/2J ENSMUSG00185019694
 protein coding gene Chr11:103720461-103786965 (-)
FVB/NJ ENSMUSG00205019940
 protein coding gene Chr11:103525944-103592440 (-)
JF1/MsJ ENSUMUG00000025981
 protein coding gene Chr11:103980898-104048667 (-)
LP/J ENSMUSG00230034589
 protein coding gene Chr11:104772651-104839148 (-)
NOD/ShiLtJ ENSMUSG00190021178
 protein coding gene Chr11:103718992-103785493 (-)
NZO/HlLtJ ENSMUSG00225051057
 protein coding gene Chr11:106808141-106874583 (-)
PWK/PhJ ENSLUMG00010015865
 protein coding gene Chr11:103502415-103570104 (-)
SPRET/EiJ ENSMSPG00010029484
 protein coding gene Chr11:104016012-104129801 (-)
WSB/EiJ ENSIUOG00005016910
 protein coding gene Chr11:103500207-103566762 (-)



Homology
more
  • Human Ortholog
    TEX2, testis expressed 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TEX2, testis expressed 2
  • Synonyms
    HT008, TMEM96
  • Links
    NCBI Gene ID: 55852
    UniProt: Q8IWB9

  • Chr Location
    17q23.3; chr17:64147227-64263291 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele are fertile and exhibit normal testis gross appearance, normal testis and epididymis histology, and normal sperm morphology and motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    65
  • cDNA Data
    11
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040548 Ensembl Gene Model | MGI Sequence Detail 111277 C57BL/6J ±  kb
    transcript ENSMUST00000042780 Ensembl | MGI Sequence Detail 4934 Not Applicable  
    polypeptide ENSMUSP00000041985 Ensembl | MGI Sequence Detail 1128 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000016256 testis-expressed protein 2
      (term hierarchy)
    • InterPro Domains
      IPR031468 Synaptotagmin-like mitochondrial-lipid-binding domain
      IPR063440 Testis-expressed protein 2, N-terminal domain
    • GlyGen
      Q6ZPJ0 9 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 13
      Genomic 1
      cDNA 12

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19302, MGI:1915001, MGI:2144222
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:18471 Lemaire L, et al., Chromosomal assignment of three novel mouse genes expressed in testicular cells. Genomics. 1994 May 15;21(2):409-14
    • Latest
      J:370030 Ogawa Y, et al., CRISPR/Cas9-mediated genome editing reveals seven testis-enriched transmembrane glycoproteins dispensable for male fertility in mice. Andrology. 2025 Jul;13(5):1251-1260
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory