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Ap2a1 Gene Detail
Summary
  • Symbol
    Ap2a1
  • Name
    adaptor-related protein complex 2, alpha 1 subunit
  • Synonyms
    Adtaa
  • Feature Type
    protein coding gene
  • IDs
    MGI:101921
    NCBI Gene: 11771
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44549797-44578914 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.01 cM, cytoband B2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    752 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101921
 protein coding gene Chr7:44549797-44578920 (-)
129S1/SvImJ ENSMUSG00200022795
 protein coding gene Chr7:32145479-32174534 (-)
A/J ENSMUSG00195038184
 protein coding gene Chr7:36173551-36202602 (-)
AKR/J ENSMUSG00220007406
 protein coding gene Chr7:30478515-30507571 (-)
BALB/cJ ENSMUSG00180037133
 protein coding gene Chr7:33048940-33077997 (-)
C3H/HeJ ENSMUSG00175032135
 protein coding gene Chr7:33581408-33610463 (-)
C57BL/6NJ ENSMUSG00215044161
 protein coding gene Chr7:32842553-32871687 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029683
 protein coding gene Chr7:46834445-46864533 (-)
CAST/EiJ ENSTCUG00005041273
 protein coding gene Chr7:36558647-36587745 (-)
CBA/J ENSMUSG00210048789
 protein coding gene Chr7:33952773-33981824 (-)
DBA/2J ENSMUSG00185046041
 protein coding gene Chr7:37825403-37854453 (-)
FVB/NJ ENSMUSG00205023740
 protein coding gene Chr7:33498091-33527216 (-)
JF1/MsJ ENSUMUG00000023915
 protein coding gene Chr7:42313509-42342571 (-)
LP/J ENSMUSG00230051592
 protein coding gene Chr7:43254775-43283947 (-)
NOD/ShiLtJ ENSMUSG00190030094
 protein coding gene Chr7:33825850-33854974 (-)
NZO/HlLtJ ENSMUSG00225015361
 protein coding gene Chr7:41463365-41492548 (-)
PWK/PhJ ENSLUMG00010040622
 protein coding gene Chr7:32782051-32811076 (-)
SPRET/EiJ ENSMSPG00010041897
 protein coding gene Chr7:32557542-32586477 (-)
WSB/EiJ ENSIUOG00005024749
 protein coding gene Chr7:34369284-34398273 (-)



Homology
more
  • Human Ortholog
    AP2A1, adaptor related protein complex 2 subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP2A1, adaptor related protein complex 2 subunit alpha 1
  • Synonyms
    ADTAA, AP2-ALPHA, CLAPA1
  • Links
    NCBI Gene ID: 160
    UniProt: O95782

  • Chr Location
    19q13.33; chr19:49766990-49807114 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    664
  • Tissues
    9
  • cDNA Data
    11
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11771 NCBI Gene Model | MGI Sequence Detail 29118 C57BL/6J ±  kb
    transcript NM_007458 RefSeq | MGI Sequence Detail 3457 C57BL/6  
    polypeptide P17426 UniProt | EBI | MGI Sequence Detail 977 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000004099 AP-2 complex subunit alpha-1
      (term hierarchy)
    • InterPro Domains
      IPR050840 Adaptor Complexes Large Subunit
      IPR017104 Adaptor protein complex AP-2, alpha subunit
      IPR011989 Armadillo-like helical
      IPR016024 Armadillo-type fold
      IPR003164 Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain
      IPR008152 Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain
      IPR013041 Clathrin adaptor, appendage, Ig-like subdomain superfamily
      IPR002553 Clathrin/coatomer adaptor, adaptin-like, N-terminal
      IPR009028 Coatomer/calthrin adaptor appendage, C-terminal subdomain
      IPR012295 TBP domain superfamily
    • GlyGen
      P17426 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 12
      Primer pair 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-18750
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 12
      Gene Ontology 22
      Phenotypes 11
    • Earliest
      J:21441 Robinson MS, Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins). J Cell Biol. 1989 Mar;108(3):833-42
    • Latest
      J:382914 Shi L, et al., FMRP-dependent translational control negatively regulates adapter protein complex 2-mediated endocytosis. iScience. 2025 Aug 15;28(8):113062
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory