Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:12885 Angel JM, et al., Localization of a novel chromosome 7 locus that suppresses development of N-Methyl-N-nitrosourea-induced murine thymic lymphomas. Mol Carcinog. 1993;7(3):151-6
• ID
  MGI:42336

Genes

Gene	Allele	Assay Type	Description
Tlag1		resistance/susceptibility
Tyr	Tyr^c	visible phenotype
Hbb		Southern analysis	pCR1(beta)M9

Notes

• Experiment
  149 (AKR/J x C57L/J)F2 mice were tested for MNU induced lymphoma tumor incidence (gene Tlag1). An association between Tlag1 and the albino locus was observed in which 50% (20/40) of c/c mice developed tumors whereas only 28% (31/109) of the nonalbino (C/C or C/c) mice did so. In 135 F2 mice there was also a significant association between Hbb and tumor incidence (19/41) over Hbb^d/s or Hbb<s/^s (26/94). There was also a significant association between Hbb and Tyr with Tlag1