Tlag1 QTL Detail

Summary

• Symbol
  Tlag1
• Name
  T lymphoma attenuation gene 1
• Synonyms
  Tls1, Tls-1

• Feature Type
  QTL
• IDs
  MGI:101804
  NCBI Gene: 110137

Location &
Maps

• Sequence Map
  Chr7:87073979-87142720 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

MNU treated AKR/J mice develop a high incidence of thymic lymphomas at 6 weeks of age, a significant acceleration over spontaneous occurrence. C57BL/J mice do not develop thymic lymphomas, and only at a low rate if MNU treated. Crosses indicate several genes may contribute, one of which is Tlag1.

Sequences &
Gene Models

• NCBI Gene
  110137

Other
Accession IDs

MGD-MRK-15134, MGD-MRK-15135, MGD-MRK-18616

References

• Summaries
  All 7

  Phenotypes 2
• Earliest
  J:10061 Angel JM, et al., Genetics of N-methyl-N-nitrosourea induction of thymic lymphomas in AKR/J mice: assignment of a susceptibility gene to mouse chromosome 7. J Natl Cancer Inst. 1989 Nov 1;81(21):1652-5
• Latest
  J:74369 Angel JM, et al., Tlag2, an N-methyl-N-nitrosourea susceptibility locus, maps to mouse chromosome 4. Mol Carcinog. 2002 Feb;33(2):105-12