Mapping Data

Experiment

• Experiment
  CROSS
• Chromosome
  6
• Reference
  J:12846 Godfrey P, et al., GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function. Nat Genet. 1993 Jul;4(3):227-32
• ID
  MGI:42215

Genes

Gene	Assay Type	Description
Tcrb	reported elsewhere
Hoxa5	reported elsewhere
Ghrhr	Southern analysis	Ghrhr cDNA1
Igk	reported elsewhere

Notes

• Reference
  Authors suggest Ghrhr is a candidate gene for the lit mutation. Authors use Hox-1.3 for Hoxa5.
• Experiment
  Offspring types indicate alleles inherited from F1 parent.
  

CROSS

• Type
  Backcross, female
• Female Parent
  <b> <b> <b> <b>/<s> <s> <s> <s>
• Strain
  (C57BL/6J x M. spretus)F1
• Male Parent
  <b> <b> <b> <b>/<b> <b> <b> <b>
• Strain
  C57BL/6J
• Mapping Panel
  Copeland-Jenkins
• Allele 1
  b from C57BL/6J
• Allele 2
  s from M. spretus

CROSS Data

MC #mice	Tcrb	Hoxa5	Ghrhr	Igk
87	b	b	b	b
80	s	s	s	s
5	s	b	b	b
4	b	s	s	s
0	s	s	b	b
1	b	b	s	s
3	s	s	s	b
3	b	b	b	s

Additional Mice Typed Only for Specific Pairs of Loci

Marker 1	Marker 2	# Recombinants	# Parentals
Tcrb	Hoxa5	0	10
Hoxa5	Ghrhr	0	3
Ghrhr	Igk	1	3

Statistics

Marker 1	Marker 2	# Recombinants	Total	% Recombinants	Std Error
Tcrb	Hoxa5	9	193	4.663	1.518
Hoxa5	Ghrhr	1	186	0.538	0.536
Ghrhr	Igk	7	187	3.743	1.388