Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:93200 Suto J, et al., Further mapping and characterization of Naq1, a quantitative trait locus responsible for maternal inferior nurturing ability in RR mice. J Vet Med Sci. 2004 Sep;66(9):1033-8
• ID
  MGI:3510706

Genes

Gene	Assay Type
Naq1	visible phenotype
D5Mit218	PCR amplified length variant
Phkg1	reported elsewhere
Mmp17	reported elsewhere
Clip2	reported elsewhere
Eif4h	reported elsewhere
Asl	reported elsewhere
Por	reported elsewhere
Cldn3	reported elsewhere
Fzd9	reported elsewhere
Cldn4	reported elsewhere
Gtf2i	reported elsewhere
Gnb2	reported elsewhere
Hspb1	reported elsewhere

Notes

• Experiment
  Previously identified QTL Naq1 (nurturing ability QTL1) was further refined and characterized in this study. 84 microsatellite markers were typed in 159 dams from a (KK x RR)F2 intercross. KK females exhibit normal nurturing ability with a pup weaning rate of 97% while RR females exhibit decreased nurturing ability with a 69.9% weaning rate.
  
  Naq1 originally mapped to 70 cM on mouse Chromosome 5 near D5Mit161. In this study peak linkage was observed at 72 cM on mouse Chromosome 5 near D5Mit218. Naq1 reaches LOD=5.5 for litter weight gain between 7 and 12 days of age, LOD=5.4 for litter weight at 12 days of age, and LOD=4.5 for litter weight at 21 days of age. The 95% confidence interval of Naq1 spans approximately 68 cM - 80 cM. Naq1 explains 15.8% of the phenotypic variance. The RR-derived allele confers decreased litter weight with a recessive mode of inheritance. Potential candidate genes identified in the Naq1 interval are Phkg1 (72 cM), Mmp17 (72.5 cM), Cyln2 (74 cM), Wbscr1 (74 cM), Asl (74 cM), Por (75 cM), Cldn3 (75 cM), Fzd9 (75 cM), Cldn4 (75 cM), Gtf2i (75 cM), Gnb2 (76 cM), and Hspb1 (76 cM).
  
  A previously identified suggestive locus at 9 cM on mouse Chromosome 9 near D9Mit90 was also detected with suggestive linkage in this study. This locusreaches LOD=2.9 for litter weight gain between 7 and 12 days of age. RR-derived alleles confer decreased litter weight with a dominant mode of inheritance.