Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  9
• Reference
  J:92924 Ohno T, et al., Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice. Immunogenetics. 2001 Dec;53(9):736-40
• ID
  MGI:3055134

Genes

Gene	Assay Type
D9Mit10
D9Mit120
D9Mit14
D9Mit214
Pymr	resistance/susceptibility
Trf
Cish
Ccr4

Notes

• Experiment
  (NC/JicJcl X 129X1/SvJMs) F1 x NC/JicJcl backcross mice were informative in mapping QTL Pymr (Plasmodium yoelli malaria resistance) to mouse Chromosome 9. Seventy six [76] polymorphic markers at an average spacing of 20 cM were used for the genome scan.
  
  The 129X1/SvJMs-derived allele at Pymr confers resistance to P. yoelli with a dominant mode of inheritance. Parental strain 129X1/SvJMs is resistant to infection with P. yoelli where as parental strain NC/JicJcl is susceptible.
  
  The host resistance locuswas designated Pymr for P. yoelii malaria resistance locus. It mapped to the telomeric portion of mouse Chr 9 between D9Mit10 and D9Mit20.
  
  The region contains three potential candidate genes: Tfr (transferrin), Cish (cytokine-inducible SH-2 containingprotein) and Cmkbr4 (chemokine receptor 4).
  
  The mapped position of Pymr is homologous to the human chromosome syntenic region 3q24-26.