Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:83831 Masinde GL, et al., Quantitative trait loci for periosteal circumference (PC): identification of single loci and epistatic effects in F(2) MRL/SJL mice. Bone. 2003 May;32(5):554-60
• ID
  MGI:2670136

Genes

Gene	Assay Type
Pcir2	visible phenotype
D11Mit36	PCR amplified length variant
Hoxb1	reported elsewhere
Hoxb2	reported elsewhere
Hoxb3	reported elsewhere
Hoxb4	reported elsewhere
Hoxb5	reported elsewhere
Hoxb6	reported elsewhere
Hoxb7	reported elsewhere
Hoxb8	reported elsewhere
Hoxb9	reported elsewhere
Wnt3	reported elsewhere
Wnt9b	reported elsewhere
Stat3	reported elsewhere
Stat5a	reported elsewhere
Stat5b	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 633 (MRL/MpJ x SJL/J)F2 animals using 137 polymorphic markers at an average spacing of 12 cM to identify QTLs associated with periosteal circumference (PC). Parental strain MRL/MpJ exhibits greater PC compared to parental strain SJL/J. (MRL/MpJ x SJL/J)F1 hybrids exhibit increased PC similar to that of the MRL/MpJ parent. Five QTLs showed significant linkage (LOD>3.5) to periosteal circumference (Pcir1-5) and 4 QTLs showed significant linkage to periosteal circumference and femur length (Pcfm1-4).
  
  Pcir1 maps to 82 cM on mouse Chromosome 1 with LOD=7.7 at D1Mit33.
  
  Pcir2 maps to 43.7 cM on mouse Chromosome 11 with LOD=3.53 at D11Mit36 and also shows linkage to body weight (LOD=3.25), muscle size (LOD=4.28), and body length (LOD=3.28). Possible candidate genes mapping near Pcir2 are the Hoxb genes 1-9, Wnt3, Wnt9b, Stat3, Stat5a, and Stat5b.
  
  Pcir3 maps to 33.4 cM on mouse Chromosome 15 with LOD=6.2 at D15Mit62.
  
  Pcir4 maps to 17 cM on mouse Chromosome 17 with LOD=4.1at D17Mit175.
  
  Pcir5 maps to 18.6 cM on mouse Chromosome X with LOD=5.1 at DXMit208. Pcir5 shows epistatic interaction with loci at D1Mit44 (linked to body weight), D2Mit62 (linked to body weight), D2Mit44, and Pcfm2.
  
  Pcfm1 and Pcfm2 map to 15.3 cM and59 cM on mouse Chromosome 2, respectively. Pcfm1 gives LOD=5.4 at D2Mit32 and Pcfm2 gives LOD=4.9 at D2Mit304.
  
  Pcfm3 maps to 37.2 cM on mouse Chromosome 3 with LOD=3.9 at D3Mit213..
  
  Pcfm4 maps to 26.2 cM on mouse Chromosome 5 with LOD=5.4 at D5Mit302.