Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  5
• Reference
  J:72229 Hurle B, et al., Physical Mapping of the Mouse Tilted Locus Identifies an Association between Human Deafness Loci DFNA6/14 and Vestibular System Development. Genomics. 2001 Oct;77(3):189-99
• ID
  MGI:2153720

Genes

Gene	Assay Type
D5Mit4
Fgfr3
Htt
D5Mit268
D5Mit75
Bloc1s4	visible phenotype
D5Mit230
D5Mit351
Wfs1
Evc
Crmp1
D5Mit182
D5Mit354
Lrpap1
Msx1
D5Mit421
Stx18
Nsg1
Otop1	visible phenotype
Slc2a9
Drd5
Wdr1
Clnk
Hs3st1
D5Mit353
D5Mit267
D5Mit128
D5Mit150
D5Mit78a
D5Mit105
Prom1
Fgfbp1
Fbxl5
Cd38
Bst1
D5Mit231
D5Mit126

Notes

• Experiment
  An F2 intersubspecific cross (C57BL/6J-tlt x M. m. castaneus) was analyzed for markers around the tlt locus on Chromosome 5. The genetic map of the Otop1 locus was integrated with the genes used in the haplotype analysis to create a comprehensive map of the region. The order and distance of the markers were determined to be: centromere - D5Mit4 - 0.2 cM - Fgfr3, Hdh, D5Mit268 - 0.3 cM - D5Mit126 - 1.6 cM - D5Mit75 - 0.9 cM - D5Mit230 - 0.1 cM - D5Mit351 - 0.1 cM - Wfs1 - 0.1 cM - Evc, Crmp1, D5Mit182 - 0.1 cM - D5Mit354 - 0.2 cM - Lrpap1, Msx1, D5Mit421 - 0.1 cM - Stx18 - 0.3 cM - Nsg1 - 0.4 cM - Slc2a9, Drd5, Wdr1 - 0.3 cM - Clnk - 0.5 cM - Hs3st1 - 0.1 cM - D5Mit353, D5Mit267, D5Mit128 - 0.3 cM - D5Mit150 - 1.1 cM - D5Mit78, D5Mit105 - 0.3 cM - Proml1, Fgfbp1, Fbxl5, Cd38, Bst1 - 0.8 cM - D5Mit231. The cno locus was narrowed to the 0.9 cM region between D5Mit75 and D5Mit230 while the tlt locus was narrowed to the 0.7 cM region between Nsg1 and Clnk.