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Phenotype Images associated with this Allele
Nomenclature
Symbol: Gmeb2em1(IMPC)J
Name: glucocorticoid modulatory element binding protein 2; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6766467
Synonyms: Gmeb2-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)J are small and developmentally delayed, show incomplete turning, mild caudal neural tube kinking, abnormal tail morphology, and abnormal head shape. A few show abnormal heart morphology. Yolk sacs are pale or abnormally vascularized.Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)JC57BL/6NJ-Gmeb2em1(IMPC)J/Mmjax
Placental abnormalities in E9.5 Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)J embryos include a diminished spongiotrophoblast layer, abnormal chorioallantoic interface and impaired branching, and multiple labyrinth zone defectsGmeb2em1(IMPC)J/Gmeb2em1(IMPC)JC57BL/6NJ-Gmeb2em1(IMPC)J/Mmjax
At E8.5, Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)J embryos are indistinguishable from controls.Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)JC57BL/6NJ-Gmeb2em1(IMPC)J/Mmjax
E9.5 Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)J embryos do not complete turning.Gmeb2em1(IMPC)J/Gmeb2em1(IMPC)JC57BL/6NJ-Gmeb2em1(IMPC)J/Mmjax
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory