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Phenotype Images associated with this Allele
Nomenclature
Symbol: Spty2d1em1(IMPC)J
Name: SPT2 chromatin protein domain containing 1; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:6294149
Synonyms: Spty2d1-
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)J (-/-) embryonic phenotype. Embryos are smaller, some have abnormally shaped heads and abnormal blood pooling. By E11.5, some start dying and those alive show abnormal blood pooling in and near the heart. A minority of embryos have abnormal hearts and pericardial enema. Yolk sac vessels are pale. All embryos are dying by E12.5.Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)JC57BL/6NJ-Spty2d1em1(IMPC)J/Mmjax
Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)J (-/-) placenta phenotypes. Placenta shows a reduction in the spongiotrophoblast layer, diminished labyrinth layer, and impaired chorioallantoic branching.Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)JC57BL/6NJ-Spty2d1em1(IMPC)J/Mmjax
E10.5 Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)J (-/-) mutants are relatively normal and display regular germ layer features and patterning.Spty2d1em1(IMPC)J/Spty2d1em1(IMPC)JC57BL/6NJ-Spty2d1em1(IMPC)J/Mmjax
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory