Phenotype Images associated with this Allele - MGI

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Phenotype Images associated with this Allele

Nomenclature

Symbol:	Arpc1a^em1(IMPC)J
Name:	actin related protein 2/3 complex, subunit 1A; endonuclease-mediated mutation 1, Jackson
MGI ID:	MGI:6275161
Synonyms:	Arpc1a^-

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	Open cranial neural tube in an E9.5 Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J embryo.	Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J	C57BL/6NJ-Arpc1a^em1(IMPC)J/Mmjax
	E9.5 Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J embryos have abnormal head shape, sometimes with incomplete cranial neural tube closure, and about half have branchial arch/pouch abnormalities and abnormal cardiac development. E10.5 embryos are dysmorphic or dying.	Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J	C57BL/6NJ-Arpc1a^em1(IMPC)J/Mmjax
	Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J (-/-) placentas have an expanded spongiotrophoblast layer, multiple labyrinth zone defects, and nearly absent chorioallantoic branching at E10.5.	Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J	C57BL/6NJ-Arpc1a^em1(IMPC)J/Mmjax
	Despite gross abnormalities including an open cranial neural tube and severely dysmorphic head and pericardial edema, all Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J embryos display appropriate germ layer patterning at E10.5.	Arpc1a^em1(IMPC)J/Arpc1a^em1(IMPC)J	C57BL/6NJ-Arpc1a^em1(IMPC)J/Mmjax

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