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Phenotype Images associated with this Allele
Nomenclature
Symbol: Fen1tm3.1Bhsh
Name: flap structure specific endonuclease 1; targeted mutation 3.1, Binghui Shen
MGI ID: MGI:5767323
Synonyms: E160D, Fen1ED
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
(a) Accumulation of apoptotic nuclei in Fen1tm3.1Bhsh/Fen1tm3.1Bhsh tissuesFen1tm3.1Bhsh/Fen1tm3.1BhshNot Specified
Deposition of IgG immune complex onto the glomeruli and capillary walls of the kidneys and onto cells in the lungs of Fen1tm3.1Bhsh/Fen1tm3.1Bhsh miceFen1tm3.1Bhsh/Fen1tm3.1BhshNot Specified
Fen1tm3.1Bhsh/Fen1tm3.1Bhsh mice are highly susceptible to cancers as a result of their mutator phenotype and chronic inflammationFen1tm3.1Bhsh/Fen1tm3.1BhshNot Specified
Fen1tm3.1Bhsh/Fen1tm3.1Bhsh mice develop subcutaneous inflammation, lymphoproliferative disorder, and extramedular hematopoiesisFen1tm3.1Bhsh/Fen1tm3.1BhshNot Specified
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory