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Phenotype Images associated with this Allele
Nomenclature
Symbol: Snx10tm1a(EUCOMM)Raba
Name: sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino
MGI ID: MGI:5690193
Synonyms: Snx10Neo-f
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba mice are growth retarded, have a tooth eruption defect and have bones that lack marrow cavitiesSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Deficiency of mineralized cortical bone in Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba miceSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba bone shows endosteum filled with unresorbed cartilage, thin cortical bone, and non-mineralized osteoid covering the mineralized trabeculaeSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Abnormal stomach in 3-week old Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba miceSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Calcium supplementation can correct the rickets phenotype of Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba miceSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Bone abnormalities in Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba Ctsktm1(cre)Ska/Ctsktm1(cre)Ska and Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba miceCtsktm1(cre)Ska/Ctsk+
Snx10tm1c(EUCOMM)Raba/Snx10tm1c(EUCOMM)Raba		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba oseoclasts are unable to acidify, have impaired endosomal pathways, and have defective ruffled bordersSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba and Tcirg1tm1Ypl/Tcirg1tm1Ypl mice show osteopetroricketsTcirg1tm1Ypl/Tcirg1tm1Yplinvolves: 129S4/SvJae * C57BL/6J
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba mice display reduced zymogenic cell granular size and abundanceSnx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Rabainvolves: 129S4/SvJae * C57BL/6 * C57BL/6J
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory