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Phenotype Image Detail
Image
Caption Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba (Snx10 KD) mice display reduced zymogenic cell granular size and abundance. A) Immunofluorescence images from stomach sections from wild-type (WT) and mutant mice stained for GIF (a zymogenic cell marker, ZC), Snx10, GSII (a marker for the mucous neck cells interspersed with the parietal cells in the neck of the gastric unit) shows Snx10-specific staining in WT zymogenic cells. B) H&E confirms the small size and high nuclear:cytoplasmic ratio of parietal cells in mutant gastric units. The zymogenic cells, lacking their abundant apical granules, are also smaller, and there are increased parietal cells in the base (ZC) zone (black arrowheads).
Copyright This image is from Ye L, PLoS Genet 2015 Mar;11(3):e1005057, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:224711
Associated
Alleles
Symbol Name
Snx10tm1a(EUCOMM)Raba sorting nexin 10; targeted mutation 1a, Ricardo A Battaglino
Associated
Genotypes
Allelic Composition Genetic Background
Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba involves: 129S4/SvJae * C57BL/6 * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory