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Phenotype Images associated with this Allele
Nomenclature
Symbol: Spo11tm1.1Gvpc
Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1.1, Galina Petukhova
MGI ID: MGI:5538688
Synonyms: Spo11Gal4
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Absence of germ cells beyond the spermatocyte stage and small ovaries with diminished number of follicles in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc mice and absence of ovarian follicles in Spo11tm1.1Gvpc/Spo11tm3Rdco miceSpo11tm1.1Gvpc/Spo11tm1.1Gvpcinvolves: C57BL/6
Spo11tm1.1Gvpc/Spo11tm3Rdcoinvolves: C57BL/6
The number of meiotic double stranded breaks is reduced in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc anf Spo11tm1.1Gvpc/Spo11tm3Rdco malesSpo11tm1.1Gvpc/Spo11tm1.1Gvpcinvolves: C57BL/6
Spo11tm1.1Gvpc/Spo11tm3Rdcoinvolves: C57BL/6
The number of meiotic double stranded breaks is reduced in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc and Spo11tm1.1Gvpc/Spo11tm1.1Gvpc Psmc3iptm1Rdco/Psmc3iptm1Rdco femalesSpo11tm1.1Gvpc/Spo11tm1.1Gvpcinvolves: C57BL/6
Psmc3iptm1Rdco/Psmc3iptm1Rdco
Spo11tm1.1Gvpc/Spo11tm1.1Gvpc		involves: 129S6/SvEvTac * C57BL/6
Double stranded break repair in Spo11tm1.1Gvpc/Spo11tm1.1Gvpc and Spo11tm1.1Gvpc/Spo11tm3Rdco spermatocytes is incompleteSpo11tm1.1Gvpc/Spo11tm1.1Gvpcinvolves: C57BL/6
Spo11tm1.1Gvpc/Spo11tm3Rdcoinvolves: C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory