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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ctsktm1.1Rbar
Name: cathepsin K; targeted mutation 1.1, Roland Baron
MGI ID: MGI:5492037
Synonyms: Ctskfl
Images for
Allele
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Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Increase in cancellous bone mass in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 miceCtsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0		involves: C57BL/6
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0		involves: C57BL/6 * CBA
Increase in cancellous bone mass in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 and Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 femursCtsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0		involves: C57BL/6
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0		involves: C57BL/6 * CBA
Increase in TRAP-positive osteoclasts in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 mice in vitroCtsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0		involves: C57BL/6 * CBA
Increase in cross-sectional bone volume and cortical bone volume in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Itgam-cre)AJva/0 femurs but not in Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Mx1-cre)1Cgn/0 or Ctsktm1.1Rbar/Ctsktm1.1Rbar Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 femursCtsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Itgam-cre)AJva/0		involves: C57BL/6
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Mx1-cre)1Cgn/0		involves: C57BL/6 * CBA
Ctsktm1.1Rbar/Ctsktm1.1Rbar
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0		involves: CD-1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory