Phenotype Image Detail

Image

Caption

Deleting Ctsk in hematopoietic cells and osteoclasts increases cancellous bone mass, bone formation and numbers of osteoblasts and osteoclasts. Histomorphometric analysis of cancellous bone in femurs from Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0 (Mx1;Ctsk^fl/fl) and Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0 (CD11b;Ctsk^fl/fl) 9-week-old mice. Original magnification, x2.

Copyright

This image is from Lotinun S, J Clin Invest 2013 Jan 16;(): and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:194492

Associated Alleles

Symbol	Name
Ctsk^tm1.1Rbar	cathepsin K; targeted mutation 1.1, Roland Baron

Associated Genotypes

Allelic Composition	Genetic Background
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Itgam-cre)AJva/0	involves: C57BL/6
Ctsk^tm1.1Rbar/Ctsk^tm1.1Rbar Tg(Mx1-cre)1Cgn/0	involves: C57BL/6 * CBA