Phenotype Images associated with this Transgene - MGI

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Phenotype Images associated with this Transgene

Nomenclature

Symbol:	A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}
Name:	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
MGI ID:	MGI:3050453
Synonyms:	alphaMHC-Cre-Mer-Cre, alpha-MHC-MerCreMer, CM-MCM, MCM, mer, mER-CRE-mER, MerCreMer, Myh6-MerCreMer, Myh6:MerCreMer, Tg(Myh6-cre/Esr1)1Jmk

Images for
Allele

Click images for details

Image	Caption	Genotypes involving this allele
Image	Caption	Allelic Composition	Genetic Background
	The Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ mouse heart is flaccid and flabby after tamoxifen induction.	Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * FVB/N
	Cardiac fibrosis in Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ mouse heart	Med1^tm2Jkr/Med1^tm2Jkr A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129P2/OlaHsd * FVB/N
	Inhibition of dilated cardiomyopathy in Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice	Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ Tg(Myh6-2A)#Know/0	involves: BALB/c * C3H * C57BL/6 * FVB/N
	Decrease in fibrosis in Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 hearts	Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ Tg(Myh6-2A)#Know/0	involves: BALB/c * C3H * C57BL/6 * FVB/N
	Enlarged hearts with thinned ventricular walls and enlarged cardiac chambers in Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice	Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
	Left ventricle Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 myocardium presents with sarcomeric disarray and swollen mitochondria and contains autophagic bodies after tamoxifen treatment	Mtor^tm1.1Gcon/Mtor^tm1.1Gcon A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

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