Phenotype Image Detail

Image

Caption

Prevention of dystrophin cleavage in Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 (Dys^KI/2A/MCM) mice inhibits enteroviral protease 2A-mediated cardiomyopathy. (A) Whole hearts from control mice, mice harboring wild-type dystrophin, protease 2A, and the MerCREMer transgenes, and mice harboring the dystrophin knockin, protease 2A, and the MerCREMer transgenes ( Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0). Hearts were taken from these mice 4 weeks after tamoxifen administration and demonstrate that dystrophin knockin inhibited the gross appearance of dilated cardiomyopathy.

Copyright

This image is from Lim BK, J Clin Invest 2013 Dec 2;123(12):5146-51 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:207775

Associated Alleles

Symbol	Name
A1cf^Tg(Myh6-cre/Esr1*)1Jmk	APOBEC1 complementation factor; transgene insertion 1, Jeffery D Molkentin
Dmd^tm1.1Know	dystrophin, muscular dystrophy; targeted mutation 1.1, Kirk Knowlton
Tg(Myh6-2A)#Know	transgene insertion, Kirk Knowlton

Associated Genotypes

Allelic Composition	Genetic Background
Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Tg(Myh6-2A)#Know/0	involves: BALB/c * C3H * C57BL/6 * FVB/N