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Phenotype Images associated with this Allele
Nomenclature
Symbol: Ccl2tm1Rol
Name: C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
MGI ID: MGI:2175911
Synonyms: CCL2-, CCL2KO, (MCP)1-, MCP-1-, MCP-1KO, Scya2-
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Retinal lesion in Ccl2tm1Rol/Ccl2tm1Rol Cx3cr1tm1Litt/Cx3cr1tm1Litt miceCcl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Retinal pigment epithelium damage, photoreceptor degeneration and amacrine cell alteration in Ccl2tm1Rol/Ccl2tm1Rol Cx3cr1tm1Litt/Cx3cr1tm1Litt miceCcl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Increased Bruch membrane thickness, vacuolated changes in retinal pigment epithelium, photoreceptor inner segment damage and outer segment disorientation in Ccl2tm1Rol/Ccl2tm1Rol Cx3cr1tm1Litt/Cx3cr1tm1Litt eyesCcl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Retinal microglial activation in different ages of Ccl2tm1Rol/Ccl2tm1Rol Cx3cr1tm1Litt/Cx3cr1tm1Litt miceCcl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J
Ccl2tm1Rol/Ccl2tm1Rol mice with experimental autoimmune encephalomyelitis show fewer inflammatory infiltrates in the spinal cordCcl2tm1Rol/Ccl2tm1RolB6.129S4-Ccl2tm1Rol

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/01/2024
MGI 6.24
The Jackson Laboratory