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Phenotype Image Detail
Image
Caption Retinal microglial activation in different ages of Ccl2tm1Rol/Ccl2tm1Rol Cx3cr1tm1Litt/Cx3cr1tm1Litt (DKO) mice. (A-F, K-M) Retinal flatmounts from double knockout (DKO) mice were stained for isolectin B4 (red) and examined by confocal microscopy. (A, C, E) Confocal images from inner plexiform layer (IPL). (B, D, F) Confocal images from outer plexiform layer (OPL). (A, B) 3-month old. (C, D), 18-month old. (E, F) 10-month+light -treatment. (G) The number of microglial cells in different groups of mice. (H) High magnification image showing activated microglia from light-treated mice. (I) High magnification image showing a naive resident microglia from a 3-month old DKO mouse. (J) High magnification image showing a CD11b+ naive resident microglia from a 3-month old wild-type mouse. (K-M) Z-axils reconstruction of confocal z-stack images from a 3-month old (K), an 18-month old (L), and 10-month+light mutant (M) mouse retina. (N-Q) RPE/choroidal flatmounts showing subretinal macrophages in 3-month old (N), an 18-month old (O), and 10-month+light (P, Q) mutant eyes. RPE cells were stained with rhodamine-phalloidin (red). (R) The number of subretinal macrophages in different groups of mice. *,P<0.05; **<0.01, n = 6. GL, Ganglion layer; PL, photoreceptor layer. Scale bar = 50 um.
Copyright This image is from Chen M, PLoS One 2013;8(4):e61381, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:200877
Associated
Alleles
Symbol Name
Ccl2tm1Rol C-C motif chemokine ligand 2; targeted mutation 1, Barrett J Rollins
Cx3cr1tm1Litt C-X3-C motif chemokine receptor 1; targeted mutation 1, Dan R Littman
Associated
Genotypes
Allelic Composition Genetic Background
Ccl2tm1Rol/Ccl2tm1Rol
Cx3cr1tm1Litt/Cx3cr1tm1Litt
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory