Phenotype Image Detail

Image

Caption

Rapid heart failure in Hnrnpu^tm1.1Tman/Hnrnpu^tm1.1Tman Tg(Ckmm-cre)5Khn/0 (Ckmm-KO) mice. (A) Reduced contraction strength in mutant hearts. Shown are B- and M-mode results of echocardiography examination of control and mutant hearts from P11 animals. The green line in the Upper panel marks the position for time lapse tracing in the Bottom panel. (B) Mutant animals quickly develop severe heart malfunction. Fractional shortening (FS) was calculated from echocardiography results with control and mutant animals of different ages (data were generated from eight control and six mutant mice). ****P < 0.0001. (C) Ckmm-Cre deletion of Hnrnpu from the heart has little effect on heart rates. Heart rates for control and mutant animals of different ages were recorded from echocardiograms.

Copyright

This image is from Ye J, Proc Natl Acad Sci U S A 2015 Jun 9;112(23):E3020-9. Copyright 2015 National Academy of Sciences, U.S.A. J:223139

Associated Alleles

Symbol	Name
Hnrnpu^tm1.1Tman	heterogeneous nuclear ribonucleoprotein U; targeted mutation 1.1, Tom Maniatis
Tg(Ckmm-cre)5Khn	transgene insertion 5, C Ronald Kahn

Associated Genotypes

Allelic Composition	Genetic Background
Hnrnpu^tm1.1Tman/Hnrnpu^tm1.1Tman Tg(Ckmm-cre)5Khn/0	involves: 129S4/SvJaeSor * FVB