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Hnrnputm1.1Tman
Targeted Allele Detail
Summary
Symbol: Hnrnputm1.1Tman
Name: heterogeneous nuclear ribonucleoprotein U; targeted mutation 1.1, Tom Maniatis
MGI ID: MGI:5648110
Synonyms: Hnrnpu f
Gene: Hnrnpu  Location: Chr1:178148673-178165362 bp, - strand  Genetic Position: Chr1, 83.16 cM
Alliance: Hnrnputm1.1Tman page
Aberrant cardiomyocyte oranization and contractility in Hnrnputm1.1Tman/Hnrnputm1.1Tman Tg(Ckmm-cre)5Khn/0 hearts

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223139
Parent Cell Line:  AK7.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA floxed neomycin resistance cassette was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 14. Cre-mediated recombination removed the selection cassette and left exons 4 through 14 floxed. (J:223139)
Generation of the Hnrnputm1.1Tman allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hnrnpu Mutation:  43 strains or lines available
References
Original:  J:223139 Ye J, et al., hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function. Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3020-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory