Phenotype Image Detail

Image

Caption

Three lysine knock-in mutation in Hivep3 (Shn3) results in hypomorphic bone phenotype. Femurs from 8 week old wild-type (Shn3^+/+), Hivep3^tm2Glm/Hivep3⁺ (Shn3^KI/+), Hivep3^tm2Glm/Hivep3^tm2Glm (Shn3^KI/KI), Hivep3^tm1Glm/Hivep3⁺ (Shn3^-/+), Hivep3^tm2Glm/Hivep3^tm1Glm (Shn3^KI/-), and Hivep3^tm1Glm/Hivep3^tm1Glm (Shn3^-/-) mice were analyzed by microCT. The "-" allele represents the previously described germline null allele. Displayed are three-dimensional reconstructions of trabecular bone, midshaft cortical bone, and bone volume/trabecular bone volume (BV/TV), trabecular number (Tb. N), trabecular thickness (Tb. Th), and cortical thickness (C. Th) parameters. Values are mean + SD. "*" indicates a significant difference by the Student's t-test, t <0.05. "***" indicates p < 0.0005 and "**" indicates p < 0.005.

Copyright

This image is from Shim JH, J Clin Invest 2013 Sep 3;123(9):4010-22 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:201597

Associated Alleles

Symbol	Name
Hivep3^tm1Glm	human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Laurie H Glimcher
Hivep3^tm2Glm	human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 2, Laurie H Glimcher

Associated Genotypes

Allelic Composition	Genetic Background
Hivep3^tm2Glm/Hivep3^tm2Glm	involves: C57BL/6
Hivep3^tm1Glm/Hivep3^+	involves: C57BL/6
Hivep3^tm1Glm/Hivep3^tm2Glm	involves: C57BL/6
Hivep3^tm1Glm/Hivep3^tm1Glm	involves: C57BL/6