Phenotype Image Detail

Image

Caption

(A-C) Tissue sections of liver, kidney and heart of control (STAT3-FF) littermates. Magnifications: x40. (D-F) Stat3^tm1Flv/Stat3^tm1Flv Tg(Tek-cre)12Flv/0 (STAT3-CFF) littermates. (D) The liver of mutant mice was infiltrated around the portal vein by neutrophils, monocytes, and other cell types (arrow 1); hepatocytes were of normal appearance (arrow 2) (x40, hematoxylin and eosin). (E) Kidney had normal glomeruli (arrow 3) and tubular structures without inflammatory cell infiltration (x40, hematoxylin and eosin). (F) Heart showed normal myocardial fibers (arrow 4) without inflammatory cell infiltration (x40, hematoxylin and eosin). Five age-and-sex matched pairs were analyzed. Pathologic alteration of the liver was observed in all mutant mice examined.

Copyright

This image is from Welte T, Proc Natl Acad Sci U S A 2003 Feb 18;100(4):1879-84. Copyright 2003 National Academy of Sciences, U.S.A. J:81973

Associated Alleles

Symbol	Name
Stat3^tm1Flv	signal transducer and activator of transcription 3; targeted mutation 1, Richard A Flavell
Tg(Tek-cre)12Flv	transgene insertion 12, Richard A Flavell

Associated Genotypes

Allelic Composition	Genetic Background
Stat3^tm1Flv/Stat3^tm1Flv Tg(Tek-cre)12Flv/0	involves: 129 * C3H * C57BL/6