Phenotype Image Detail

Image

Caption

A-F: Representative images of E18.5 littermate control (A, C, E & G) and Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex} Sulf2^{Gt(OST311938)Lex}/Sulf2^{Gt(OST311938)Lex} (B, D, F & H) fetuses double stained with alcian blue and alizarin red to demonstrate skeletal elements. A & B: Whole mount images demonstrating the reduced size of the double mutant skeleton. All bones are present, and no obvious fusion defects are apparent in any class of joints. C & D: Skulls viewed from the posterios side. Note the hole in the dorsal side of the basisphenoid bone of the double mutant skeleton (to the right in D). Also note that the palate appears to be developing properly. E-H: Rib cages (skeletal double staining; e, F) and sternum (thresholded CT; G,H) revealing sternebral asymmetry about the midline in double mutant mice (black arrowheads in F, and yellow arrowhead in H). The 4^th and 5^th sternebrae (counting from rostral to caudal) have a slender site of ossification bridging them at the midline (f, with another example in panel H [yellow arrow]). Scale bars: 1mm

Copyright

This image is from Holst CR, PLoS ONE 2007;2(6):e575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:129305

Associated Alleles

Symbol	Name
Sulf1^Gt(OST352220)Lex	sulfatase 1; gene trap OST352220, Lexicon Genetics
Sulf1^Gt(OST352220)Lex	sulfatase 1; gene trap OST352220, Lexicon Genetics
Sulf2^Gt(OST311938)Lex	sulfatase 2; gene trap OST311938, Lexicon Genetics
Sulf2^Gt(OST311938)Lex	sulfatase 2; gene trap OST311938, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Sulf1^Gt(OST352220)Lex/Sulf1^Gt(OST352220)Lex Sulf2^Gt(OST311938)Lex/Sulf2^Gt(OST311938)Lex	involves: 129S5/SvEvBrd * C57BL/6N