Sulf1^{Gt(OST352220)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Sulf1^{Gt(OST352220)Lex}
• Name: sulfatase 1; gene trap OST352220, Lexicon Genetics
• MGI ID: MGI:3769469
• Synonyms: Sulf1^{GT(VICTR48)352220Lex}
• Gene: Sulf1 Location: Chr1:12762501-12931416 bp, + strand Genetic Position: Chr1, 3.35 cM
• Alliance: Sulf1^{Gt(OST352220)Lex} page

Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex} Sulf2^{Gt(OST311938)Lex}/Sulf2^{Gt(OST311938)Lex} embryos display several development defects

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: OST352220
• Germline Transmission: Earliest citation of germline transmission: J:129305
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The VICTOR48 gene trap vector that contains a promoterless lacZ gene and a neo cassette was inserted into intron 2. Q-RT-PCR confirmed a near absence of expression of the transcript in the lung,spleen and mammary gland and lowered expression in the testes. (J:129305)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST352220	CG633011 ; (MGI Seq Detail)	3' RACE	Chr1:12856831-12857059 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  78 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sulf1 Mutation: 110 strains or lines available

Notes

See also, data as provided by Lexicon Genetics, Inc.

References

• Original: J:129305 Holst CR, et al., Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One. 2007;2(6):e575
• All: 3 reference(s)