Phenotypes associated with this allele

• Allele Symbol: Sulf1^{Gt(OST352220)Lex}
• Allele Name: gene trap OST352220, Lexicon Genetics
• Allele ID: MGI:3769469
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sulf1^Gt(OST352220)Lex/Sulf1^Gt(OST352220)Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:3769475
cx2	Sulf1^Gt(OST352220)Lex/Sulf1^Gt(OST352220)Lex Sulf2^Gt(OST311938)Lex/Sulf2^Gt(OST311938)Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:3769477

Genotype
MGI:3769475

hm1

• Allelic Composition: Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to bacterial infection ( J:171883 )

• homozygous mutant mice exhibited a decreased mean IL-6 response to LPS challenge when compared with controls

Genotype
MGI:3769477

cx2

• Allelic Composition: Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex}; Sulf2^{Gt(OST311938)Lex}/Sulf2^{Gt(OST311938)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

Sulf1^{Gt(OST352220)Lex}/Sulf1^{Gt(OST352220)Lex} Sulf2^{Gt(OST311938)Lex}/Sulf2^{Gt(OST311938)Lex} embryos display several development defects

mortality/aging

decreased survivor rate ( J:129305 )

• long term survival is 18%

premature death ( J:129305 )

• some mice that survive weaning die within 10 days of weaning

• long term survival is 18%

neonatal lethality, incomplete penetrance ( J:129305 )

• fewer than expected mice survive postnatal day 1 to 2 and die with empty stomachs

postnatal lethality ( J:129305 )

• few mice that survive past the first week of life survive to weaning

growth/size/body

decreased body weight ( J:129305 )

• mice weigh 19% less than wild-type mice

• at week 14 to 15, male mice weigh 26% less than wild-type mice and female mice weigh 29% less than wild-type mice

decreased body length ( J:129305 )

• mice measure 12% less in length than wild-type mice

skeleton

abnormal basisphenoid bone morphology ( J:129305 )

• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone

abnormal sternebra morphology ( J:129305 )

• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice

sternebra fusion ( J:129305 )

• at E18.5, 12 of 14 mice exhibit asymmetric and/or fused sternebrae compared to only 1 of 19 wild-type mice

decreased bone volume ( J:129305 )

• bone volume is decreased in the humerus (by 21.4%), femur (by 15.7%), frontal (by 6.8%), interparietal (by 15.3%, supraoccipital (by 22.6%), basioccipital (by 15.5%, and basiphenoid (by 13.6%)

decreased chondrocyte number ( J:129305 )

• the distal chondrocyte population is smaller than in wild-type mice

renal/urinary system

small kidney ( J:129305 )

• kidney volume is reduced 45% compared to in heterogygous mice

craniofacial

abnormal basisphenoid bone morphology ( J:129305 )

• the posterior basisphenoid bone fails to fuse and is aberrantly fused to the basioccipital bone