Gene Expression Image Detail

Reference

Figure

ID

J:41878 Zoltewicz JS, et al., Development. 1999 Nov;126(22):5085-95

3

MGI:1346350

Image

Caption

Mildly affected embryos (wild-type in A,C and oto in B,D) have defects in the midline of the telencephalic vesicles, indicated by red arrowheads. (C,D) red arrowhead, commissural plate; blue arrowhead, isthmus. (E,F) blue arrowhead, ventral diencephalon; red arrowhead, ventral telencephalon. The expression pattern of Nkx2.1 in moderately (G,H) and severely (I,J) affected embryos reveals loss of ventral telencephalon. The narrowing of the diencephalic expression domain at the anterior (blue arrowheads in F,H,J) is the result of loss of the preoptic region. (K) Wild-type embryo. blue arrowhead, dorsal telencephalon; red arrowhead, ventral telencephalon. (L) blue arrowhead, reduced telencephalic vesicle of an oto embryo. Double-label in situ hybridization shows the expression of Otx2 (in magenta) and Shh (in purple) in wild-type (M) and oto (N) embryos.

Copyright

This image is from Zoltewicz et al., Development 126:5085-5095 (1999), and is displayed with the permission of The Company of Biologists Limited who owns the Copyright.

Associated
Assays

Label	Assay & Result Details (Gene Symbol)	Spatial Mapping
D	MGI:1346415 (Fgf8)
E	MGI:1346416 (Nkx2-1)	EMAGE:448
F	MGI:1346416 (Nkx2-1)	EMAGE:448
G	MGI:1346416 (Nkx2-1)
H	MGI:1346416 (Nkx2-1)
I	MGI:1346416 (Nkx2-1)
J	MGI:1346416 (Nkx2-1)
K	MGI:1346419 (Pax6)
L	MGI:1346419 (Pax6)
C	MGI:1346415 (Fgf8)
M	MGI:1346420 (Otx2) MGI:1346421 (Shh)
N	MGI:1346420 (Otx2) MGI:1346421 (Shh)