Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	PIK3CA	HGNC:8975 (HGNC) 5290 (Entrez Gene) 171834 (OMIM) PIK3CA (Alliance of Genome Resources)	Chr3 q26.32	Chr3:179148114-179240093 (+) GRCh38	breast angiosarcoma breast cancer cerebral cavernous malformation CLOVES syndrome colon adenocarcinoma colorectal cancer colorectal carcinoma Cowden syndrome 5 cutaneous Paget's disease epidermal nevus estrogen-receptor positive breast cancer hepatocellular carcinoma ovarian cancer rectal benign neoplasm seborrheic keratosis stomach cancer	P42336 (UniProt | EBI) NM_006218 (RefSeq)
mouse	Pik3ca	MGI:1206581 (MGI) 18706 (Entrez Gene) Gene Tree Pik3ca (Alliance of Genome Resources)	Chr3 15.7 cM	Chr3:32451203-32520256 (+) GRCm39	breast cancer CLOVES syndrome	18706 (NCBI Gene Model) P42337 (UniProt | EBI) NM_008839 (RefSeq)
rat	Pik3ca	RGD:620916 (Rat Genome Database) 170911 (Entrez Gene) Pik3ca (Alliance of Genome Resources)	Chr2 q24			A0A0G2K344 (UniProt | EBI) NM_133399 (RefSeq)
zebrafish	pik3ca	ZDB-GENE-130409-1 (Zebrafish Model Organism Database) 561737 (Entrez Gene) pik3ca (Alliance of Genome Resources)	Chr11			XP_021335549 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.