Vertebrate Homology

• Source: Alliance of Genome Resources

Multiple Genome Viewer

Comparative GO Graph (mouse, human, rat, zebrafish)  

Alliance Homology Information

Species	Symbol	Gene Links	Genetic Location	Genome Coordinates (mouse and human only)	Associated Human Diseases	Sequences
human	POMC	HGNC:9201 (HGNC) 5443 (Entrez Gene) 176830 (OMIM) POMC (Alliance of Genome Resources)	Chr2 p23.3	Chr2:25160853-25168903 (-) GRCh38	familial mediterranean fever obesity osteoarthritis	P01189 (UniProt | EBI) NM_001319205 (RefSeq)
mouse	Pomc	MGI:97742 (MGI) 18976 (Entrez Gene) Gene Tree Pomc (Alliance of Genome Resources)	Chr12 1.99 cM	Chr12:4004951-4010642 (+) GRCm39	obesity	ENSMUSG00000020660 (Ensembl Gene Model) ENSMUSP00000151504 (Ensembl) ENSMUST00000219543 (Ensembl)
rat	Pomc	RGD:3366 (Rat Genome Database) 24664 (Entrez Gene) Pomc (Alliance of Genome Resources)	Chr6 q14			P01194 (UniProt | EBI) NM_139326 (RefSeq)
zebrafish	pomca	ZDB-GENE-030513-2 (Zebrafish Model Organism Database) 353221 (Entrez Gene) pomca (Alliance of Genome Resources)	Chr17			NP_852103 (RefSeq) NM_181438 (RefSeq)
	pomcb	ZDB-GENE-041014-294 (Zebrafish Model Organism Database) 100034412 (Entrez Gene) pomcb (Alliance of Genome Resources)	Chr20			NP_001076520 (RefSeq) NM_001083051 (RefSeq)

Alliance Homology Information

MGI loads orthology data based on the 'stringent' set from the Alliance of Genome Resources. The Alliance sets are based on a scoring system developed by the Alliance in collaboration with DIOPT.

MGI includes orthology for the following vertebrate species from the Alliance:
 - human
 - mouse
 - rat
 - zebrafish

These are a subset of the total species represented in the Alliance; there may be stringent set orthologs in other Alliance species.