Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ZIC4
  • Mouse genes Zic4
  • Rat genes Zic4
  • Zfish genes zic4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Zic4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003677	DNA binding	Zic4	IDA		Mouse	PMID:15465018
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	Zic4	IDA		Mouse	PMID:18298960
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ZIC4	IDA		Human	PMID:28473536
Cellular Component	GO:0005634	nucleus	Zic4	IDA		Mouse	PMID:15465018
Biological Process	GO:0021534	cell proliferation in hindbrain	zic4	IGI	ZFIN:ZDB-MRPHLNO-080514-2,ZFIN:ZDB-MRPHLNO-080514-3,ZFIN:ZDB-MRPHLNO-080514-6	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-7	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-6	Zfish	PMID:18191121
Biological Process	GO:0021592	fourth ventricle development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-5	Zfish	PMID:18191121
Biological Process	GO:0030902	hindbrain development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-5	Zfish	PMID:18191121
Biological Process	GO:0030902	hindbrain development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-7	Zfish	PMID:18191121
Biological Process	GO:0030902	hindbrain development	zic4	IMP	ZFIN:ZDB-MRPHLNO-080514-6	Zfish	PMID:18191121

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern