Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes WNK2
  • Mouse genes Wnk2
  • Rat genes Wnk2
  • Zfish genes wnk2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Wnk2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Cellular Component	GO:0005737	cytoplasm	WNK2	IDA		Human	PMID:17667937
Cellular Component	GO:0005829	cytosol	WNK2	IDA		Human	GO_REF:0000052
Biological Process	GO:0050801	monoatomic ion homeostasis	WNK2	IMP		Human	PMID:21733846
Biological Process	GO:0008285	negative regulation of cell population proliferation	WNK2	IMP		Human	PMID:17667937
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	WNK2	IMP		Human	PMID:17667937
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	WNK2	IMP		Human	PMID:23797875
Biological Process	GO:2000651	positive regulation of sodium ion transmembrane transporter activity	WNK2	IMP		Human	PMID:21733846
Biological Process	GO:0046777	protein autophosphorylation	WNK2	IDA		Human	PMID:17667937
Biological Process	GO:0006468	protein phosphorylation	WNK2	IDA		Human	PMID:21733846
Biological Process	GO:0006468	protein phosphorylation	Wnk2	IDA		Mouse	MGI:MGI:5294501|PMID:21733846

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern