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Wnk2
Gene Detail
Symbol

Name
ID
Wnk2
WNK lysine deficient protein kinase 2
MGI:1922857
Synonyms
1810073P09Rik, ESTM15, mKIAA1760, X83337
Feature Type
protein coding gene
Genetic Map
Chromosome 13
25.07 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:49036303-49148012 bp, - strand
From VEGA annotation of GRCm38

  111710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19155  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: WNK2
Gene Tree: Wnk2

Human
homologs
WNK2, WNK lysine deficient protein kinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 65268
neXtProt AC: NX_Q9Y3S1

Human Synonyms: NY-CO-43, P/OKcl.13, PRKWNK2, SDCCAG43

Human Chr (Location): 9q22.3; chr9:93184155-93320572 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Wnk2 interacts with 206 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process negative regulation of cell proliferation, negative regulation of ERK1 and ERK2 cascade, ...
Component cytoplasm, membrane, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (55)    Tissues (6)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(69)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035035 (Evidence)
Ensembl Gene Model ENSMUSG00000037989 (Evidence)
Entrez Gene 75607 (Evidence)
UniGene 342723
DFCI TC1601798, TC1591921, TC1578548, TC1631972, TC1655024, TC1657082
DoTS DT.102555972, DT.101735347, DT.101345946, DT.91331353, DT.87042645, DT.91551380
NIA Mouse Gene Index U034756
EC 2.7.11.1
Consensus CDS Project CCDS70454.1, CCDS70455.1
International Mouse Phenotyping Consortium Status Wnk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035035 VEGA Gene Model | MGI Sequence Detail 111710 C57BL/6J ±  kb
transcript OTTMUST00000089108 VEGA | MGI Sequence Detail 6584 Not Applicable 
polypeptide OTTMUSP00000048645 VEGA | MGI Sequence Detail 2137 Not Applicable 

For the selected sequences
All sequences(116) RefSeq(40) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(431 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR024678 Serine/threonine-protein kinase OSR1/WNK, CCT domain
Protein Ontology PR:000017432 serine/threonine-protein kinase WNK2
References
(Earliest) J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
(Latest) J:212614 Dutruel C, et al., Early epigenetic downregulation of WNK2 kinase during pancreatic ductal adenocarcinoma development. Oncogene. 2014 Jun 26;33(26):3401-10
All references(37)
Other
accession IDs
MGD-MRK-28128, MGI:104834, MGI:2145415

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory