Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VRK1
  • Mouse genes Vrk1
  • Rat genes Vrk1
  • Zfish genes vrk1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vrk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0042393	histone binding	VRK1	IPI	UniProtKB:P0C0S8	Human	PMID:22194607
Molecular Function	GO:0035175	histone H3S10 kinase activity	VRK1	IDA		Human	PMID:22194607
Molecular Function	GO:0072354	histone H3T3 kinase activity	VRK1	IDA		Human	PMID:22194607
Molecular Function	GO:0140677	molecular function activator activity	VRK1	IDA		Human	PMID:33076429
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P15336	Human	PMID:15105425
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P05412	Human	PMID:15378002
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P04637	Human	PMID:15542844
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P62826	Human	PMID:18617507
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:Q9H4B4	Human	PMID:19103756
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P38432	Human	PMID:21920476
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:O75367	Human	PMID:22194607
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:Q12888	Human	PMID:22621922
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P04637	Human	PMID:24492002
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P05412	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P16104	Human	PMID:25923214
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:O60934	Human	PMID:26869104
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:O76064	Human	PMID:26869104
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P48431	Human	PMID:27334688
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:P04637	Human	PMID:29340707
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:Q96GD4	Human	PMID:29340707
Molecular Function	GO:0005515	protein binding	VRK1	IPI	UniProtKB:Q92993	Human	PMID:33076429
Molecular Function	GO:0004672	protein kinase activity	VRK1	IDA		Human	PMID:22194607
Molecular Function	GO:0019901	protein kinase binding	VRK1	IDA		Human	PMID:22572157
Molecular Function	GO:0004674	protein serine/threonine kinase activity	VRK1	IDA		Human	PMID:21543316
Molecular Function	GO:0004674	protein serine/threonine kinase activity	VRK1	IDA		Human	PMID:33076429
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Vrk1	IDA		Mouse	MGI:MGI:6867109|PMID:33076429
Molecular Function	GO:0004674	protein serine/threonine kinase activity	Vrk1	IDA		Mouse	PMID:14645249
Cellular Component	GO:0005829	cytosol	VRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005795	Golgi stack	VRK1	IDA		Human	PMID:19103756
Cellular Component	GO:0005730	nucleolus	VRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	VRK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	VRK1	IDA		Human	PMID:22194607
Cellular Component	GO:0005634	nucleus	Vrk1	IDA		Mouse	PMID:14645249
Biological Process	GO:0006974	DNA damage response	VRK1	IDA		Human	PMID:33076429
Biological Process	GO:0090166	Golgi disassembly	VRK1	IDA		Human	PMID:19103756
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	VRK1	IDA		Human	PMID:33076429
Biological Process	GO:0046777	protein autophosphorylation	VRK1	IDA		Human	PMID:21543316
Biological Process	GO:0046777	protein autophosphorylation	VRK1	IDA		Human	PMID:22194607
Biological Process	GO:0046777	protein autophosphorylation	Vrk1	IDA		Mouse	PMID:14645249
Biological Process	GO:0006468	protein phosphorylation	Vrk1	IDA		Mouse	PMID:14645249

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern