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Vrk1
Gene Detail
 Symbol
Name
ID
Vrk1
vaccinia related kinase 1
MGI:1261847
Synonyms 51PK
Feature Type protein coding gene
Genetic Map
Chromosome 12
56.37 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:106010263-106077410 bp, + strand
From NCBI annotation of GRCm38

  67148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Vrk1

Human
homologs
Human Homolog VRK1, vaccinia related kinase 1
NCBI Gene ID 7443
neXtProt AC  NX_Q99986
Human Synonyms  PCH1, PCH1A
Human Chr (Location)  14q32; chr14:96797347-96881614 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human VRK1
Alleles
and
phenotypes
All alleles(44) : Gene trapped(44)
 
Homozygotes for a gene trap allele yielding nearly full-length protein levels are fertile and overtly normal. Homozygotes for a hypomorphic gene trap allele are sterile; male infertility is due to progressive loss of proliferating spermatogonia leading to lack of meiotic cells and mature sperm.
 
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (38)    Tissues (38)   
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RT-PCR 38
cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(71) cDNA(70) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021115 (Evidence)
Entrez Gene22367 (Evidence)
UniGene2981
DFCITC1578193, TC1586885, TC1587723, TC1595892, TC1596228
DoTSDT.101380488, DT.91336814, DT.91576177, DT.91576278, DT.94128848, DT.99847044
NIA Mouse Gene IndexU014354
EC2.7.11.1
Consensus CDS ProjectCCDS26157.1, CCDS26158.1, CCDS36551.1
International Mouse Knockout Project StatusVrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22367 NCBI Gene Model | MGI Sequence Detail 67148 C57BL/6J ±  kb
transcript NM_011705 RefSeq | MGI Sequence Detail 3796 C57BL/6 
polypeptide Q80X41 UniProt | EBI | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(30) UniProt(4)
Polymorphisms SNPs within 2kb(676 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000017349 serine/threonine-protein kinase VRK1
Graphical View of Protein Domain Structure
References (Earliest) J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
(Latest) J:207272 Kim J, et al., Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1. Sci Rep. 2012;2:468
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory