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Vrk1 Gene Detail
Summary
  • Symbol
    Vrk1
  • Name
    vaccinia related kinase 1
  • Synonyms
    51PK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261847
    NCBI Gene: 22367
  • Gene Overview
    MyGene.info: VRK1
Location & Maps
more
  • Sequence Map
    Chr12:106010263-106077410 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67148 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 56.37 cM, cytoband F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    VRK1, vaccinia related kinase 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    VRK1, vaccinia related kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PCH1, PCH1A
  • Links
    NCBI Gene ID: 7443
    neXtProt AC: NX_Q99986

  • Chr Location
    14q32.2; chr14:96797347-96881614 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2541
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VRK1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human VRK1 associations

Human Disease Mouse Models
       Pontocerebellar Hypoplasia, Type 1A; PCH1A   OMIM: 607596
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    45
  • Chemically induced (other)
    1
  • Gene trapped
    44
  • Genomic Mutations
    1 involving Vrk1
  • Incidental Mutations
Homozygotes for a gene trap allele yielding nearly full-length protein levels are fertile and overtly normal. Homozygotes for a hypomorphic gene trap allele are sterile; male infertility is due to progressive loss of proliferating spermatogonia leading to lack of meiotic cells and mature sperm.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021115 Ensembl Gene Model | MGI Sequence Detail 67148 C57BL/6J ±  kb
transcript ENSMUST00000021539 Ensembl | MGI Sequence Detail 3796 Not Applicable  
polypeptide ENSMUSP00000021539 Ensembl | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    679 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    cDNA 70
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 13
  • Earliest
    J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
  • Latest
    J:218891 Vinograd-Byk H, et al., The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-beta precursor protein-dependent mechanism. J Neurosci. 2015 Jan 21;35(3):936-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory