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Vrk1
Gene Detail
Symbol

Name
ID
Vrk1
vaccinia related kinase 1
MGI:1261847
Synonyms
51PK
Feature Type
protein coding gene
Genetic Map
Chromosome 12
56.37 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:106010263-106077410 bp, + strand
From Ensembl annotation of GRCm38

  67148 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2541  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: VRK1
Gene Tree: Vrk1

Human
homologs
VRK1, vaccinia related kinase 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7443
neXtProt AC: NX_Q99986

Human Synonyms: PCH1, PCH1A

Human Chr (Location): 14q32; chr14:96797347-96881614 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human VRK1

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(44)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a gene trap allele yielding nearly full-length protein levels are fertile and overtly normal. Homozygotes for a hypomorphic gene trap allele are sterile; male infertility is due to progressive loss of proliferating spermatogonia leading to lack of meiotic cells and mature sperm.
 
Interactions
Vrk1 interacts with 253 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell cycle, cell division, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, histone kinase activity (H3-S10 specific), ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (38)    Tissues (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 38
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vrk1    NEW 
Molecular
reagents
All nucleic(71) cDNA(70) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000021115 (Evidence)
Entrez Gene 22367 (Evidence)
UniGene 2981
DFCI TC1596228, TC1578193, TC1595892, TC1587723, TC1586885
DoTS DT.101380488, DT.91576278, DT.91576177, DT.91336814, DT.99847044, DT.94128848
NIA Mouse Gene Index U014354
EC 2.7.11.1
Consensus CDS Project CCDS26157.1, CCDS26158.1, CCDS36551.1
International Mouse Phenotyping Consortium Status Vrk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021115 Ensembl Gene Model | MGI Sequence Detail 67148 C57BL/6J ±  kb
transcript ENSMUST00000021539 Ensembl | MGI Sequence Detail 3796 Not Applicable 
polypeptide ENSMUSP00000021539 Ensembl | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(22) UniProt(4)
Polymorphisms
SNPs within 2kb(676 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000017349 serine/threonine-protein kinase VRK1
References
(Earliest) J:46795 Zelko I, et al., Molecular cloning and characterization of a novel nuclear protein kinase in mice. Arch Biochem Biophys. 1998 Apr 1;352(1):31-6
(Latest) J:207272 Kim J, et al., Defective folliculogenesis in female mice lacking Vaccinia-related kinase 1. Sci Rep. 2012;2:468
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory