Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAV2
  • Mouse genes Vav2
  • Rat genes Vav2
  • Zfish genes vav2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vav2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005154	epidermal growth factor receptor binding	Vav2	IPI	PR:Q01279	Mouse	PMID:15728722
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	VAV2	EXP		Human	PMID:8990121
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	Vav2	IMP		Mouse	PMID:15728722
Molecular Function	GO:0001784	phosphotyrosine residue binding	VAV2	IPI	UniProtKB:Q6GX35	Human	PMID:20624904
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:P78314	Human	PMID:11390470
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:P78314	Human	PMID:15345594
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:P51956	Human	PMID:15618286
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:P04626	Human	PMID:16273093
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:O75674	Human	PMID:18654987
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:Q8IZP0	Human	PMID:20598684
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:Q03135	Human	PMID:20808760
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:Q13480	Human	PMID:24728074
Molecular Function	GO:0005515	protein binding	VAV2	IPI	UniProtKB:Q9H3M7	Human	PMID:26919541
Molecular Function	GO:0005515	protein binding	Vav2	IPI	UniProtKB:Q03145	Mouse	MGI:MGI:3640033|PMID:16782872
Molecular Function	GO:0005515	protein binding	Vav2	IPI	PR:Q8VC66	Mouse	PMID:22027834
Cellular Component	GO:0005737	cytoplasm	Vav2	IDA		Mouse	PMID:15728722
Cellular Component	GO:0005886	plasma membrane	Vav2	IDA		Mouse	PMID:15728722
Biological Process	GO:0016477	cell migration	Vav2	IGI	MGI:MGI:1888518	Mouse	PMID:15728722
Biological Process	GO:0030031	cell projection assembly	Vav2	IGI	MGI:MGI:1888518	Mouse	PMID:15728722
Biological Process	GO:0030032	lamellipodium assembly	Vav2	IGI	MGI:MGI:1888518	Mouse	PMID:15728722
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Vav2	IGI	MGI:MGI:1888518	Mouse	PMID:15728722
Biological Process	GO:0008361	regulation of cell size	VAV2	IGI	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:Q9UKW4	Human	PMID:22467863
Biological Process	GO:0043087	regulation of GTPase activity	VAV2	IGI	UniProtKB:P15498,UniProtKB:P35241,UniProtKB:Q9UKW4	Human	PMID:22467863
Biological Process	GO:0007264	small GTPase mediated signal transduction	Vav2	IMP		Mouse	PMID:15728722

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern