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Vav2
Gene Detail
 Symbol
Name
ID
Vav2
vav 2 oncogene
MGI:102718
Synonyms 2810040F13Rik
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr2:27262104-27427033 bp, - strand
From VEGA annotation of GRCm38

  164930 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: vav transforming protein
Gene Tree: Vav2

Human
homologs
Human Homolog VAV2, vav 2 guanine nucleotide exchange factor
NCBI Gene ID 7410
neXtProt AC  NX_P52735
Human Synonyms  VAV-2
Human Chr (Location)  9q34.1; chr9:133761894-133992374 (-)  GRCh38
Alleles
and
phenotypes
All alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses.
 
Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process angiogenesis, cell migration, ...
Component cytoplasm, intracellular, ...
Function epidermal growth factor receptor binding, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (79)    Tissues (49)    Images (19)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 33
RT-PCR 46
cDNA source data(99)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(101) cDNA(99) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000012034 (Evidence)
Ensembl Gene ModelENSMUSG00000009621 (Evidence)
Entrez Gene22325 (Evidence)
UniGene179011
DFCITC1577637, TC1587139
DoTSDT.101393406, DT.50315927, DT.94401155
NIA Mouse Gene IndexU022442
Consensus CDS ProjectCCDS15827.1
International Mouse Knockout Project StatusVav2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012034 VEGA Gene Model | MGI Sequence Detail 164930 C57BL/6J ±  kb
transcript OTTMUST00000028609 VEGA | MGI Sequence Detail 5221 Not Applicable 
polypeptide OTTMUSP00000012940 VEGA | MGI Sequence Detail 868 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(12) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(929 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain
InterPro IPR001715 Calponin homology domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR011511 Variant SH3
Protein Ontology PR:000017266 guanine nucleotide exchange factor VAV2
References (Earliest) J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
(Latest) J:209098 Gmyrek GB, et al., Loss of DAP12 and FcRgamma drives exaggerated IL-12 production and CD8(+) T cell response by CCR2(+) Mo-DCs. PLoS One. 2013;8(10):e76145
All references(94)
Other
accession IDs
MGD-MRK-19622, MGI:1919946, MGI:2139071

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory