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Vav2 Gene Detail
Summary
  • Symbol
    Vav2
  • Name
    vav 2 oncogene
  • Synonyms
    2810040F13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102718
    NCBI Gene: 22325
Location & Maps
more
  • Sequence Map
    Chr2:27262104-27427033 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      164930 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VAV2, vav guanine nucleotide exchange factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VAV2, vav guanine nucleotide exchange factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    VAV-2
  • Links
    NCBI Gene ID: 7410
    neXtProt AC: NX_P52735

  • Chr Location
    9q34.1; chr9:133761894-133992374 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    67 phenotypes from multigenic genotypes
    3 images
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Homozygous null mutants have defects in humoral immune response to type II thymus-independent antigens, in primary response to thymus-dependent antigens and inability to switch immunoglobulin class, form germinal centers and generate secondary responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012034 VEGA Gene Model | MGI Sequence Detail 164930 C57BL/6J ±  kb
transcript OTTMUST00000028609 VEGA | MGI Sequence Detail 5221 Not Applicable  
polypeptide OTTMUSP00000012940 VEGA | MGI Sequence Detail 868 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    929 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 101
    cDNA 99
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-19622, MGI:1919946, MGI:2139071
References
more
  • Summaries
    All 95
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 52
  • Earliest
    J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
  • Latest
    J:224528 Zhu S, et al., Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking. Nat Neurosci. 2015 Aug;18(8):1084-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory