Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes VAPB
  • Mouse genes Vapb
  • Rat genes Vapb
  • Zfish genes vapb
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Vapb

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048487	beta-tubulin binding	VAPB	IDA		Human	PMID:17540579
Molecular Function	GO:0045296	cadherin binding	VAPB	HDA		Human	PMID:25468996
Molecular Function	GO:0019899	enzyme binding	VAPB	IPI	UniProtKB:P04406	Human	PMID:17540579
Molecular Function	GO:0033149	FFAT motif binding	VAPB	IMP		Human	PMID:18713837
Molecular Function	GO:0033149	FFAT motif binding	VAPB	IPI	UniProtKB:O95772	Human	PMID:24105263
Molecular Function	GO:0033149	FFAT motif binding	VAPB	IPI	UniProtKB:Q14849	Human	PMID:24105263
Molecular Function	GO:0008017	microtubule binding	VAPB	IDA		Human	PMID:18713837
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O93077	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q03463:PRO_0000278740	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9P0L0	Human	PMID:16227268
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9P035	Human	PMID:18160438
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q03137	Human	PMID:18555774
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q5T4F4	Human	PMID:19289470
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9Y2K6	Human	PMID:19615732
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P33175	Human	PMID:21976701
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q5T4F4	Human	PMID:21976701
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96TC7	Human	PMID:22131369
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O95070	Human	PMID:23736259
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q99IB8:PRO_0000045600	Human	PMID:25616068
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P50402	Human	PMID:25910212
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9P0L0	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q14849	Human	PMID:28377464
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96LZ7	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9BXW6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9Y2K6	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9BXW6	Human	PMID:29858488
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9HB20	Human	PMID:30659099
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9NTJ5	Human	PMID:30659099
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96RL7	Human	PMID:30741634
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9Y2K6	Human	PMID:31515488
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:A0A024R8A9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O00155	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O00559	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O14684	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O15209	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P11912	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P49447	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q13520	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q15125	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q53TN4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q5VTQ0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q6P5S7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q7Z5P4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q86VR2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q8N5M9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q8N6L7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q8TBP5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96IK0	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96LZ7	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q96MV8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9GZR5	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9H6H4	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9NQQ7-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9NVV5-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9NY72	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9Y320	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:O00560	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P63010-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q0P5N6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9BYQ4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:Q9GZS3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P23763	Human	PMID:9920726
Molecular Function	GO:0005515	protein binding	VAPB	IPI	UniProtKB:P63027	Human	PMID:9920726
Molecular Function	GO:0005515	protein binding	Vapb	IPI	UniProtKB:Q3TXX3	Mouse	MGI:MGI:5606143|PMID:24251978
Molecular Function	GO:0046982	protein heterodimerization activity	VAPB	IPI	UniProtKB:Q9P0L0	Human	PMID:16227268
Molecular Function	GO:0046982	protein heterodimerization activity	VAPB	IPI	UniProtKB:Q9P0L0	Human	PMID:9920726
Molecular Function	GO:0042803	protein homodimerization activity	VAPB	IPI	UniProtKB:O95292	Human	PMID:16227268
Molecular Function	GO:0042803	protein homodimerization activity	VAPB	IPI	UniProtKB:O95292	Human	PMID:17540579
Molecular Function	GO:0042803	protein homodimerization activity	VAPB	IPI	UniProtKB:O95292	Human	PMID:9920726
Cellular Component	GO:0005737	cytoplasm	VAPB	IDA		Human	PMID:25468996
Cellular Component	GO:0005783	endoplasmic reticulum	VAPB	IDA		Human	PMID:15372378
Cellular Component	GO:0005783	endoplasmic reticulum	VAPB	IDA		Human	PMID:16891305
Cellular Component	GO:0005783	endoplasmic reticulum	VAPB	IDA		Human	PMID:18713837
Cellular Component	GO:0005789	endoplasmic reticulum membrane	VAPB	IDA		Human	PMID:16227268
Cellular Component	GO:0005794	Golgi apparatus	VAPB	IDA		Human	PMID:16227268
Cellular Component	GO:0016020	membrane	Vapb	IDA		Mouse	MGI:MGI:3693380|PMID:14561759
Biological Process	GO:0090114	COPII-coated vesicle budding	VAPB	IMP		Human	PMID:18713837
Biological Process	GO:0007029	endoplasmic reticulum organization	VAPB	IMP		Human	PMID:18713837
Biological Process	GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	VAPB	IMP		Human	PMID:18713837
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	VAPB	IMP		Human	PMID:16891305
Biological Process	GO:0006874	intracellular calcium ion homeostasis	VAPB	IMP		Human	PMID:22131369
Biological Process	GO:0036498	IRE1-mediated unfolded protein response	VAPB	IDA		Human	PMID:20940299
Biological Process	GO:0045070	positive regulation of viral genome replication	VAPB	IMP		Human	PMID:16227268
Biological Process	GO:0008016	regulation of heart contraction	vapb	IMP	ZFIN:ZDB-MRPHLNO-130625-1	Zfish	PMID:29879376
Biological Process	GO:0008016	regulation of heart contraction	vapb	IGI	ZFIN:ZDB-MRPHLNO-130625-1,ZFIN:ZDB-MRPHLNO-200130-3	Zfish	PMID:29879376
Biological Process	GO:0036269	swimming behavior	vapb	IMP	ZFIN:ZDB-MRPHLNO-130625-1	Zfish	PMID:23446633

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern