Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes UCP1
  • Mouse genes Ucp1
  • Rat genes Ucp1
  • Zfish genes ucp1
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Ucp1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0019003	GDP binding	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Molecular Function	GO:0005525	GTP binding	Ucp1	IDA		Rat	PMID:12479871|RGD:11541112
Molecular Function	GO:0036041	long-chain fatty acid binding	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	Ucp1	IMP		Mouse	MGI:MGI:4837058|PMID:20416274
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	Ucp1	IDA		Mouse	PMID:12910269
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	Ucp1	IDA		Rat	PMID:16451125|RGD:1624981
Molecular Function	GO:0017077	oxidative phosphorylation uncoupler activity	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Molecular Function	GO:0005515	protein binding	Ucp1	IPI	PR:O70302	Mouse	PMID:12910269
Molecular Function	GO:0032555	purine ribonucleotide binding	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Molecular Function	GO:0022857	transmembrane transporter activity	UCP1	IDA		Human	PMID:24196960
Molecular Function	GO:0022857	transmembrane transporter activity	Ucp1	IMP		Rat	PMID:12479871|RGD:11541112
Cellular Component	GO:0005740	mitochondrial envelope	Ucp1	IDA		Mouse	PMID:12910269
Cellular Component	GO:0005743	mitochondrial inner membrane	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Cellular Component	GO:0005739	mitochondrion	UCP1	IDA		Human	PMID:9054939
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Mouse	MGI:MGI:5805363|PMID:22952235
Cellular Component	GO:0005739	mitochondrion	Ucp1	HDA		Mouse	PMID:18614015
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Mouse	PMID:17923681
Cellular Component	GO:0005739	mitochondrion	Ucp1	HDA		Mouse	PMID:14651853
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Mouse	PMID:11940593
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Mouse	PMID:26767982
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Rat	PMID:16814247|RGD:1624980
Cellular Component	GO:0005739	mitochondrion	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Biological Process	GO:1990845	adaptive thermogenesis	Ucp1	IMP		Mouse	MGI:MGI:87392|PMID:9139827
Biological Process	GO:1990845	adaptive thermogenesis	Ucp1	IMP		Mouse	MGI:MGI:5796063|PMID:27027295
Biological Process	GO:0050873	brown fat cell differentiation	Ucp1	IEP		Mouse	MGI:MGI:2663940|PMID:15567149
Biological Process	GO:0050873	brown fat cell differentiation	Ucp1	IDA		Mouse	PMID:28763438
Biological Process	GO:0070417	cellular response to cold	Ucp1	IDA		Mouse	PMID:28763438
Biological Process	GO:1903495	cellular response to dehydroepiandrosterone	Ucp1	IEP		Rat	PMID:12659879|RGD:2313629
Biological Process	GO:0071391	cellular response to estrogen stimulus	ucp1	IDA		Zfish	PMID:18618001
Biological Process	GO:0071398	cellular response to fatty acid	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Biological Process	GO:0071398	cellular response to fatty acid	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Biological Process	GO:0032870	cellular response to hormone stimulus	Ucp1	IMP		Mouse	MGI:MGI:5796063|PMID:27027295
Biological Process	GO:0032870	cellular response to hormone stimulus	Ucp1	IEP		Rat	PMID:18079609|RGD:2313533
Biological Process	GO:0034614	cellular response to reactive oxygen species	Ucp1	IMP		Mouse	MGI:MGI:5796063|PMID:27027295
Biological Process	GO:0002024	diet induced thermogenesis	Ucp1	IMP		Mouse	MGI:MGI:3838084|PMID:19187776
Biological Process	GO:1990542	mitochondrial transmembrane transport	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Biological Process	GO:1990542	mitochondrial transmembrane transport	Ucp1	IMP		Mouse	MGI:MGI:4837058|PMID:20416274
Biological Process	GO:1990542	mitochondrial transmembrane transport	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Biological Process	GO:0006839	mitochondrial transport	Ucp1	IDA		Rat	PMID:16814247|RGD:1624980
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Ucp1	IMP		Mouse	MGI:MGI:5913742|PMID:28630339
Biological Process	GO:1902600	proton transmembrane transport	UCP1	IDA		Human	PMID:24196960
Biological Process	GO:1902600	proton transmembrane transport	Ucp1	IDA		Mouse	MGI:MGI:5444314|PMID:23063128
Biological Process	GO:1902600	proton transmembrane transport	Ucp1	IMP		Rat	PMID:12479871|RGD:11541112
Biological Process	GO:1902600	proton transmembrane transport	Ucp1	IDA		Rat	PMID:16814247|RGD:1624980
Biological Process	GO:1902600	proton transmembrane transport	Ucp1	IMP		Rat	PMID:20416274|RGD:11541111
Biological Process	GO:1902600	proton transmembrane transport	Ucp1	IDA		Rat	PMID:22952235|RGD:11541104
Biological Process	GO:1903426	regulation of reactive oxygen species biosynthetic process	Ucp1	IMP		Mouse	MGI:MGI:4837058|PMID:20416274
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Ucp1	IDA		Mouse	PMID:17670746
Biological Process	GO:0031667	response to nutrient levels	Ucp1	IMP		Mouse	MGI:MGI:3838084|PMID:19187776
Biological Process	GO:0009266	response to temperature stimulus	Ucp1	IMP		Mouse	MGI:MGI:3838084|PMID:19187776

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern