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Gene Ontology Browser
Term Detail
GO term:oxidative phosphorylation uncoupler activity
Synonym: mitochondrial uncoupling protein activity
Synonym: uncoupling protein activity
GO id:GO:0017077
Definition:Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis.
Number of paths to term: 1

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-atransporter activity
                        is-atransmembrane transporter activity
                                is-aacetate ester transmembrane transporter activity +
                                is-aactive transmembrane transporter activity +
                                is-adrug transmembrane transporter activity +
                                is-aefflux transmembrane transporter activity +
                                is-agalactosamine transmembrane transporter activity +
                                is-ahydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances +
                                is-airon chelate transmembrane transporter activity +
                                is-alipo-chitin oligosaccharide transmembrane transporter activity +
                                is-aorganic hydroxy compound transmembrane transporter activity +
                                is-aorganic phosphonate transmembrane transporter activity +
                                is-aoxidative phosphorylation uncoupler activity [GO:0017077] (2 genes, 3 annotations)
                                        is-ahydrophobic uncoupler:proton antiporter activity
                                is-apassive transmembrane transporter activity +
                                is-aphosphate transmembrane transporter activity +
                                is-apoly-beta-1,6-N-acetyl-D-glucosamine transmembrane transporter activity
                                is-asalt transmembrane transporter activity +
                                is-asubstrate-specific transmembrane transporter activity +
                                is-asulfur compound transmembrane transporter activity +
                                is-atransmembrane electron transfer carrier +
                                is-atransmembrane transporter activity involved in import into cell
                                is-auptake transmembrane transporter activity +
                                is-avitamin transmembrane transporter activity +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory