Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TXNRD2
  • Mouse genes Txnrd2
  • Rat genes Txnrd2
  • Zfish genes txnrd2.2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Txnrd2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005515	protein binding	TXNRD2	IPI	UniProtKB:O75528	Human	PMID:20413580
Molecular Function	GO:0042803	protein homodimerization activity	Txnrd2	IDA		Rat	PMID:9988709|RGD:61776
Molecular Function	GO:0044877	protein-containing complex binding	Txnrd2	IDA		Rat	PMID:14607844|RGD:5133693
Molecular Function	GO:0004791	thioredoxin-disulfide reductase activity	Txnrd2	IDA		Rat	PMID:9988709|RGD:61776
Cellular Component	GO:0030424	axon	Txnrd2	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005737	cytoplasm	Txnrd2	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005829	cytosol	TXNRD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030425	dendrite	Txnrd2	IDA		Rat	PMID:20620191|RGD:5133712
Cellular Component	GO:0005739	mitochondrion	TXNRD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005739	mitochondrion	TXNRD2	IDA		Human	PMID:10215850
Cellular Component	GO:0005739	mitochondrion	Txnrd2	IDA		Mouse	MGI:MGI:1353094|PMID:10721726
Cellular Component	GO:0005739	mitochondrion	Txnrd2	IDA		Mouse	PMID:18775783
Cellular Component	GO:0005739	mitochondrion	Txnrd2	IDA		Rat	PMID:9988709|RGD:61776
Cellular Component	GO:0043025	neuronal cell body	Txnrd2	IDA		Rat	PMID:20620191|RGD:5133712
Biological Process	GO:0045454	cell redox homeostasis	TXNRD2	IMP		Human	PMID:24601690
Biological Process	GO:0007507	heart development	Txnrd2	IMP	MGI:MGI:3512409	Mouse	PMID:15485910
Biological Process	GO:0030097	hemopoiesis	Txnrd2	IMP	MGI:MGI:3512409	Mouse	PMID:15485910
Biological Process	GO:0055093	response to hyperoxia	Txnrd2	IEP		Rat	PMID:20493230|RGD:5133717
Biological Process	GO:0010269	response to selenium ion	Txnrd2	IEP		Rat	PMID:15792362|RGD:5133718
Biological Process	GO:0009410	response to xenobiotic stimulus	Txnrd2	IEP		Rat	PMID:18790005|RGD:5134340

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern