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Txnrd2
Gene Detail
Symbol

Name
ID
Txnrd2
thioredoxin reductase 2
MGI:1347023
Synonyms
ESTM573010, TGR, TR3, TR beta
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr16:18426417-18479073 bp, + strand
From VEGA annotation of GRCm38

  52657 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4701  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: dihydrolipoamide dehydrogenase
Gene Tree: Txnrd2

Human
homologs
Human Homolog TXNRD2, thioredoxin reductase 2
NCBI Gene ID 10587
neXtProt AC  NX_Q9NNW7
Human Synonyms  SELZ, TR, TR3, TR-BETA, TRXR2
Human Chr (Location)  22q11.21; chr22:19875518-19941992 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Genomic Mutations involving Txnrd2 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele die at E13 due to severe anemia and growth retardation, resulting from perturbed cardiac development and augmented apoptosis of hematopoietic cells.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Txnrd2 interacts with 51 markers (Mir19b-2, Mir23a, Mir30a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell redox homeostasis, heart development, ...
Component axon, cytoplasm, ...
Function flavin adenine dinucleotide binding, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (204)    Tissues (135)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 158
RT-PCR 46
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(5) cDNA(10) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000026082 (Evidence)
Ensembl Gene ModelENSMUSG00000075704 (Evidence)
Entrez Gene26462 (Evidence)
DFCITC1580436, TC1667256, TC1709810
DoTSDT.101723958, DT.110733055, DT.531101, DT.97411057
NIA Mouse Gene IndexU016896
EC1.8.1.9
PDB1ZDL, 1ZKQ, 3DGZ
International Mouse Knockout Project StatusTxnrd2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026082 VEGA Gene Model | MGI Sequence Detail 52657 C57BL/6J ±  kb
transcript OTTMUST00000064390 VEGA | MGI Sequence Detail 1905 Not Applicable 
polypeptide OTTMUSP00000031965 VEGA | MGI Sequence Detail 524 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013027 FAD-dependent pyridine nucleotide-disulphide oxidoreductase
InterPro IPR016156 FAD/NAD-linked reductase, dimerisation
InterPro IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
InterPro IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation
InterPro IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain
InterPro IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
InterPro IPR006338 Thioredoxin/glutathione reductase selenoprotein
Protein Ontology PR:000016872 thioredoxin reductase 2, mitochondrial
References
(Earliest) J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
(Latest) J:199601 Chandler JD, et al., Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense. J Biol Chem. 2013 Jun 21;288(25):18421-8
All references(54)
Other
accession IDs
MGI:1338029

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory