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Txnrd2 Gene Detail
Summary
  • Symbol
    Txnrd2
  • Name
    thioredoxin reductase 2
  • Synonyms
    ESTM573010, TGR, TR3, TR beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347023
    NCBI Gene: 26462
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:18426384-18479073 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52690 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 11.41 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TXNRD2, thioredoxin reductase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TXNRD2, thioredoxin reductase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCCD5, SELZ, TR, TR3, TR-BETA, TRXR2
  • Links
    NCBI Gene ID: 10587
    neXtProt AC: NX_Q9NNW7
    UniProt: Q9NNW7

  • Chr Location
    22q11.21; chr22:19875518-19941992 (-)  GRCh38.p7

Human Diseases
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  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die at E13 due to severe anemia and growth retardation, resulting from perturbed cardiac development and augmented apoptosis of hematopoietic cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026082 VEGA Gene Model | MGI Sequence Detail 52690 C57BL/6J ±  kb
    transcript OTTMUST00000064390 VEGA | MGI Sequence Detail 1905 Not Applicable  
    polypeptide OTTMUSP00000031965 VEGA | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      5 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000016872 thioredoxin reductase 2, mitochondrial
    • PDB
    • EC
    • InterPro Domains
      IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
      IPR023753 FAD/NAD(P)-binding domain
      IPR036188 FAD/NAD(P)-binding domain superfamily
      IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
      IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
      IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
      IPR006338 Thioredoxin/glutathione reductase selenoprotein
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 5
      cDNA 10
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1338029
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 10
      Diseases 5
      Gene Ontology 10
      Phenotypes 58
    • Earliest
      J:54501 Lund J, et al., Sequence-ready physical map of the mouse chromosome 16 region with conserved synteny to the human velocardiofacial syndrome region on 22q11.2. Mamm Genome. 1999 May;10(5):438-43
    • Latest
      J:257058 Liu C, et al., Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors. Oncotarget. 2018 Jan 12;9(4):4773-4786

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory