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Gene Ontology Browser
Term Detail
GO term:thioredoxin-disulfide reductase activity
Synonym: NADPH2:oxidized thioredoxin oxidoreductase activity
Synonym: NADPH:oxidized thioredoxin oxidoreductase activity
Synonym: NADPH--thioredoxin reductase activity
Synonym: NADP--thioredoxin reductase activity
Synonym: thioredoxin disulfide reductase activity
Synonym: thioredoxin-disulphide reductase activity
Synonym: thioredoxin:NADP+ oxidoreductase activity
Synonym: thioredoxin reductase (NADPH) activity
GO id:GO:0004791
Definition:Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-aantioxidant activity
                        is-aglutathione dehydrogenase (ascorbate) activity
                        is-aglutathione-disulfide reductase activity
                        is-aperoxidase activity +
                        is-asulfiredoxin activity
                        is-asuperoxide dismutase activity
                        is-asuperoxide reductase activity
                        is-athioredoxin-disulfide reductase activity [GO:0004791] (5 genes, 6 annotations)


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on a sulfur group of donors
                                        is-aoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
                                                is-a2-oxopropyl-CoM reductase (carboxylating) activity
                                                is-aalkyl hydroperoxide reductase activity
                                                is-aasparagusate reductase activity
                                                is-abis-gamma-glutamylcystine reductase activity
                                                is-aCoA-disulfide reductase activity
                                                is-aCoA-glutathione reductase activity
                                                is-acystine reductase activity
                                                is-adihydrolipoyl dehydrogenase activity
                                                is-aglutathione-disulfide reductase activity
                                                is-ahypotaurine dehydrogenase activity
                                                is-amycothione reductase activity
                                                is-aprotein-disulfide reductase activity
                                                is-aselenodiglutathione-disulfide reductase activity
                                                is-asulfite reductase (NADPH) activity
                                                is-athioredoxin-disulfide reductase activity [GO:0004791] (5 genes, 6 annotations)
                                                is-atrypanothione-disulfide reductase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-aoxidoreductase activity
                                is-aoxidoreductase activity, acting on NAD(P)H
                                        is-aoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
                                                is-a2-oxopropyl-CoM reductase (carboxylating) activity
                                                is-aalkyl hydroperoxide reductase activity
                                                is-aasparagusate reductase activity
                                                is-abis-gamma-glutamylcystine reductase activity
                                                is-aCoA-disulfide reductase activity
                                                is-aCoA-glutathione reductase activity
                                                is-acystine reductase activity
                                                is-adihydrolipoyl dehydrogenase activity
                                                is-aglutathione-disulfide reductase activity
                                                is-ahypotaurine dehydrogenase activity
                                                is-amycothione reductase activity
                                                is-aprotein-disulfide reductase activity
                                                is-aselenodiglutathione-disulfide reductase activity
                                                is-asulfite reductase (NADPH) activity
                                                is-athioredoxin-disulfide reductase activity [GO:0004791] (5 genes, 6 annotations)
                                                is-atrypanothione-disulfide reductase activity


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory