Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TWF2
  • Mouse genes Twf2
  • Rat genes Twf2
  • Zfish genes twf2b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Twf2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003785	actin monomer binding	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Molecular Function	GO:0003785	actin monomer binding	Twf2	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Molecular Function	GO:0005524	ATP binding	TWF2	IDA		Human	PMID:10406962
Molecular Function	GO:0045296	cadherin binding	TWF2	HDA		Human	PMID:25468996
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Molecular Function	GO:0005515	protein binding	TWF2	IPI	UniProtKB:Q9NYB0	Human	PMID:21044950
Molecular Function	GO:0005080	protein kinase C binding	TWF2	IPI	UniProtKB:P09217	Human	PMID:10406962
Molecular Function	GO:0003723	RNA binding	TWF2	HDA		Human	PMID:22658674
Cellular Component	GO:0005737	cytoplasm	TWF2	IDA		Human	PMID:25468996
Cellular Component	GO:0070062	extracellular exosome	TWF2	HDA		Human	PMID:19199708
Cellular Component	GO:0030175	filopodium	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0030426	growth cone	TWF2	IDA		Human	PMID:17910947
Cellular Component	GO:0030027	lamellipodium	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0030016	myofibril	Twf2	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0032420	stereocilium	Twf2	IDA		Mouse	MGI:MGI:5285166|PMID:19955359
Biological Process	GO:0051016	barbed-end actin filament capping	Twf2	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Biological Process	GO:0071363	cellular response to growth factor stimulus	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0071300	cellular response to retinoic acid	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Twf2	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Biological Process	GO:0045773	positive regulation of axon extension	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0010592	positive regulation of lamellipodium assembly	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0010976	positive regulation of neuron projection development	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0032956	regulation of actin cytoskeleton organization	TWF2	IMP		Human	PMID:17910947
Biological Process	GO:0042989	sequestering of actin monomers	Twf2	IDA		Mouse	MGI:MGI:3840765|PMID:18837697

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern