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Twf2 Gene Detail
Summary
  • Symbol
    Twf2
  • Name
    twinfilin actin binding protein 2
  • Synonyms
    A6-related, Ptk9l, Twf2, Twinfilin-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346078
    NCBI Gene: 23999
  • Gene Overview
    MyGene.info: TWF2
Location & Maps
more
  • Sequence Map
    Chr9:106203108-106215389 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12282 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 57.46 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TWF2, twinfilin actin binding protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TWF2, twinfilin actin binding protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A6r, A6RP, MSTP011, PTK9L
  • Links
    NCBI Gene ID: 11344
    neXtProt AC: NX_Q6IBS0

  • Chr Location
    3p21.1; chr3:52228610-52239167 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 images
    11 phenotype references
  • All Mutations and Alleles
    39
  • Chemically induced (ENU)
    1
  • Gene trapped
    34
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a targeted allele are viable, fertile, and do not display obvious morphological or behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049421 VEGA Gene Model | MGI Sequence Detail 12282 C57BL/6J ±  kb
transcript OTTMUST00000125990 VEGA | MGI Sequence Detail 1596 Not Applicable  
polypeptide OTTMUSP00000068180 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    95 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 68
    cDNA 66
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143188
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:56491 Rohwer A, et al., Cloning, expression and characterization of an A6-related protein. Eur J Biochem. 1999 Jul;263(2):518-25
  • Latest
    J:222159 Li Y, et al., Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Nature. 2015 May 28;521(7553):520-4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory