Twf2 MGI Mouse Gene Detail - MGI:1346078 - twinfilin actin binding protein 2

Symbol

Twf2
Name

twinfilin actin binding protein 2
Synonyms

A6-related, Ptk9l, Twf2, Twinfilin-2

Feature Type

protein coding gene
IDs

MGI:1346078
NCBI Gene: 23999
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr9:106080307-106092586 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.46 cM
Mapping Data

2 experiments

SNPs within 2kb

337 from dbSNP Build 142
Strain Annotations

30

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346078	protein coding gene	Chr9:106080307-106092588 (+)
129S1/SvImJ	ENSMUSG00200042927	protein coding gene	Chr9:103292099-103300794 (+)
129S1/SvImJ	ENSMUSGG00200054931	protein coding gene	Chr9:103288374-103289484 (+)
A/J	ENSMUSGG00195055006	protein coding gene	Chr9:102513356-102514466 (+)
A/J	ENSMUSG00195033923	protein coding gene	Chr9:102517082-102525777 (+)
AKR/J	ENSMUSG00220022378	protein coding gene	Chr9:102906521-102915216 (+)
AKR/J	ENSMUSGG00220054415	protein coding gene	Chr9:102902802-102903912 (+)
BALB/cJ	ENSMUSG00180020140	protein coding gene	Chr9:102833550-102842247 (+)
BALB/cJ	ENSMUSGG00180055523	protein coding gene	Chr9:102829831-102830941 (+)
C3H/HeJ	ENSMUSGG00175054702	protein coding gene	Chr9:103172238-103173348 (+)
C3H/HeJ	ENSMUSG00175038512	protein coding gene	Chr9:103175965-103184660 (+)
C57BL/6NJ	ENSMUSG00215022184	protein coding gene	Chr9:103133525-103142114 (+)
C57BL/6NJ	ENSMUSGG00215055745	protein coding gene	Chr9:103129864-103130974 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032614	protein coding gene	Chr9:101592592-101605054 (+)
CAST/EiJ	ENSTCUG00005027957	protein coding gene	Chr9:102931117-102939721 (+)
CBA/J	ENSMUSGG00210054674	protein coding gene	Chr9:103000158-103001268 (+)
CBA/J	ENSMUSG00210039199	protein coding gene	Chr9:103003863-103012546 (+)
DBA/2J	ENSMUSG00185032115	protein coding gene	Chr9:103178231-103186926 (+)
DBA/2J	ENSMUSGG00185057846	protein coding gene	Chr9:103174508-103175618 (+)
FVB/NJ	ENSMUSG00205042091	protein coding gene	Chr9:103180811-103189506 (+)
FVB/NJ	ENSMUSGG00205054610	protein coding gene	Chr9:103177083-103178193 (+)
JF1/MsJ	ENSUMUG00000022548	protein coding gene	Chr9:102991532-103000117 (+)
LP/J	ENSMUSG00230050228	protein coding gene	Chr9:103327434-103336129 (+)
LP/J	ENSMUSGG00230055372	protein coding gene	Chr9:103323712-103324822 (+)
NOD/ShiLtJ	ENSMUSG00190043039	protein coding gene	Chr9:102819037-102827732 (+)
NOD/ShiLtJ	ENSMUSGG00190055047	protein coding gene	Chr9:102815306-102816416 (+)
NZO/HlLtJ	ENSMUSG00225024251	protein coding gene	Chr9:103552866-103565401 (+)
PWK/PhJ	ENSLUMG00010037275	protein coding gene	Chr9:102940790-102949376 (+)
SPRET/EiJ	ENSMSPG00010035570	protein coding gene	Chr9:104813924-104822679 (+)
WSB/EiJ	ENSIUOG00005037345	protein coding gene	Chr9:102257731-102266431 (+)

Human Ortholog

TWF2, twinfilin actin binding protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TWF2, twinfilin actin binding protein 2
Synonyms

A6r, A6RP, MSTP011, PTK9L
Links

HGNC:9621

NCBI Gene ID: 11344

UniProt: Q6IBS0
Chr Location

3p21.2; chr3:52228612-52246788 (-) GRCh38

MGI Vertebrate Homology

Twf2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TWF2
Gene Tree

Twf2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 images
15 phenotype references

All Mutations and Alleles

33
Chemically induced (ENU)

1
Endonuclease-mediated

1
Gene trapped

27
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available

Mice homozygous for a targeted allele are viable, fertile, and do not display obvious morphological or behavioral abnormalities.

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All GO Annotations

48
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

101
cDNA Data

67
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase twf2

ZFIN twf2b

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All Sequences

69
RefSeq

2
UniProt

5
CCDS

CCDS23473.1

Ensembl

ENSMUSG00000023277 (Evidence)
NCBI Gene

23999

			Length	Strain/Species	Flank
genomic	23999	NCBI Gene Model \| MGI Sequence Detail	12280	C57BL/6J	± kb
transcript	NM_011876	RefSeq \| MGI Sequence Detail	1594	C57BL/6
polypeptide	Q9Z0P5	UniProt \| EBI \| MGI Sequence Detail	349	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016845 twinfilin-2

(term hierarchy)
PDB

7DS3
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR028458 Twinfilin
GlyGen

Q9Z0P5 1 site, 1 O-linked glycan (1 site)

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All nucleic 69

cDNA 67

Primer pair 2

Microarray probesets 3

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MGI:2143188

Summaries

All 56

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 15
Earliest

J:56491 Rohwer A, et al., Cloning, expression and characterization of an A6-related protein. Eur J Biochem. 1999 Jul;263(2):518-25
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Twf2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86863	Chr9:106080307-106080370 (+)	32 bp
Tssr86864	Chr9:106080389-106080400 (+)	88 bp
Tssr86865	Chr9:106083988-106084003 (+)	3,689 bp
Tssr86866	Chr9:106088798-106088819 (+)	8,502 bp
Tssr86867	Chr9:106089373-106089403 (+)	9,081 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29