Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TWF1
  • Mouse genes Twf1
  • Rat genes Twf1
  • Zfish genes twf1a,twf1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Twf1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	TWF1	IDA		Human	PMID:28493397
Molecular Function	GO:0003785	actin monomer binding	Twf1	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Molecular Function	GO:0003785	actin monomer binding	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Molecular Function	GO:0005524	ATP binding	TWF1	IDA		Human	PMID:10406962
Molecular Function	GO:0045296	cadherin binding	TWF1	HDA		Human	PMID:25468996
Molecular Function	GO:0005546	phosphatidylinositol-4,5-bisphosphate binding	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Molecular Function	GO:0005515	protein binding	TWF1	IPI	UniProtKB:P63261	Human	PMID:28493397
Molecular Function	GO:0005515	protein binding	TWF1	IPI	UniProtKB:P67870	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Twf1	IPI	UniProtKB:P68135	Mouse	MGI:MGI:6092872|PMID:17360616
Molecular Function	GO:0004713	protein tyrosine kinase activity	Twf1	IDA		Mouse	MGI:MGI:894526|PMID:9249064
Molecular Function	GO:0044877	protein-containing complex binding	Twf1	IPI	PR:000035900	Mouse	PMID:11604420
Cellular Component	GO:0015629	actin cytoskeleton	Twf1	IDA		Mouse	MGI:MGI:1353109|PMID:10669753
Cellular Component	GO:0005911	cell-cell junction	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0005829	cytosol	TWF1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0030175	filopodium	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0005925	focal adhesion	TWF1	HDA		Human	PMID:21423176
Cellular Component	GO:0030016	myofibril	Twf1	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Cellular Component	GO:0048471	perinuclear region of cytoplasm	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Cellular Component	GO:0032587	ruffle membrane	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Biological Process	GO:0051016	barbed-end actin filament capping	Twf1	IDA		Mouse	MGI:MGI:3840765|PMID:18837697
Biological Process	GO:0030837	negative regulation of actin filament polymerization	Twf1	IDA		Mouse	MGI:MGI:2673741|PMID:12807912
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	Twf1	IDA		Mouse	MGI:MGI:5882879|PMID:20571053
Biological Process	GO:0043538	regulation of actin phosphorylation	TWF1	IDA		Human	PMID:10406962
Biological Process	GO:0042989	sequestering of actin monomers	Twf1	IDA		Mouse	MGI:MGI:3840765|PMID:18837697

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern