Twf1 MGI Mouse Gene Detail - MGI:1100520 - twinfilin actin binding protein 1

Twf1 Gene Detail

Symbol

Twf1
Name

twinfilin actin binding protein 1
Synonyms

A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1

Feature Type

protein coding gene
IDs

MGI:1100520
NCBI Gene: 19230
Gene Overview

MyGene.info: TWF1

Sequence Map

Chr15:94577951-94589889 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

11939 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 48.59 cM, cytoband F1
Mapping Data

2 experiments

Human Ortholog

TWF1, twinfilin actin binding protein 1

Vertebrate Orthologs

10

Human Ortholog

TWF1, twinfilin actin binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

A6, PTK9
Links

HGNC:9620

NCBI Gene ID: 5756

neXtProt AC: NX_Q12792
Chr Location

12q12; chr12:43793723-43806375 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 48140
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: TWF1
Protein SuperFamily

probable tyrosine kinase
Gene Tree

Twf1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
28 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

8
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Twf1
Incidental Mutations

Mutagenetix , APF

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All GO Annotations

24
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

160
Tissues

107
cDNA Data

15
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase twf1

ZFIN twf1a, twf1b

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Twf1 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

38
RefSeq

4
UniProt

2
CCDS

CCDS27773.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017538	VEGA Gene Model \| MGI Sequence Detail	11939	C57BL/6J	± kb
transcript	OTTMUST00000042612	VEGA \| MGI Sequence Detail	3025	Not Applicable
polypeptide	OTTMUSP00000019148	VEGA \| MGI Sequence Detail	350	Not Applicable

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SNPs within 2kb

107 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000016844 twinfilin-1
PDB

1M4J, 2D8B, 2HD7, 3DAW
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain

IPR028458 Twinfilin

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All nucleic 18

cDNA 16

Primer pair 2

Microarray probesets 7

Summaries

All 39

Developmental Gene Expression 6

Diseases 1

Gene Ontology 8

Phenotypes 28
Earliest

J:41824 Beeler JF, et al., Cloning and characterization of the mouse homolog of the human A6 gene. Gene. 1997 Jul 1;193(1):31-7
Latest

J:219210 Nikolaou KC, et al., Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. EMBO J. 2015 Feb 12;34(4):430-47

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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