Twf1 MGI Mouse Gene Detail - MGI:1100520 - twinfilin actin binding protein 1

Symbol

Twf1
Name

twinfilin actin binding protein 1
Synonyms

A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1

Feature Type

protein coding gene
IDs

MGI:1100520
NCBI Gene: 19230
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:94475832-94487770 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 48.59 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

96 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1100520	protein coding gene	Chr15:94475829-94487870 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022261	protein coding gene	Chr15:96049730-96061686 (-)
A/J	MGP_AJ_G0022220	protein coding gene	Chr15:92312617-92324573 (-)
AKR/J	MGP_AKRJ_G0022195	protein coding gene	Chr15:95102083-95114039 (-)
BALB/cJ	MGP_BALBcJ_G0022226	protein coding gene	Chr15:92477160-92489093 (-)
C3H/HeJ	MGP_C3HHeJ_G0021996	protein coding gene	Chr15:95119004-95130929 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022671	protein coding gene	Chr15:99566908-99579510 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020197	protein coding gene	Chr15:88339602-88351717 (-)
CAST/EiJ	MGP_CASTEiJ_G0021518	protein coding gene	Chr15:95935285-95947936 (-)
CBA/J	MGP_CBAJ_G0021963	protein coding gene	Chr15:102919925-102932658 (-)
DBA/2J	MGP_DBA2J_G0022090	protein coding gene	Chr15:91759007-91770962 (-)
FVB/NJ	MGP_FVBNJ_G0022069	protein coding gene	Chr15:90762159-90774114 (-)
LP/J	MGP_LPJ_G0022161	protein coding gene	Chr15:96167662-96179681 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022089	protein coding gene	Chr15:107214174-107227580 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022686	protein coding gene	Chr15:95185056-95197012 (-)
PWK/PhJ	MGP_PWKPhJ_G0021259	protein coding gene	Chr15:91816068-91828586 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021093	protein coding gene	Chr15:94926846-94939164 (-)
WSB/EiJ	MGP_WSBEiJ_G0021567	protein coding gene	Chr15:95688235-95700200 (-)

Human Ortholog

TWF1, twinfilin actin binding protein 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TWF1, twinfilin actin binding protein 1
Synonyms

A6, PTK9
Links

HGNC:9620

NCBI Gene ID: 5756

neXtProt AC: NX_Q12792

UniProt: Q12792
Chr Location

12q12; chr12:43793723-43806375 (-) GRCh38.p7

Alliance of Genome Resources

Twf1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TWF1
Gene Tree

Twf1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Twf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

30
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

866
Tissues

107
cDNA Data

17
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase twf1

ZFIN twf1a, twf1b

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Twf1 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

53
RefSeq

8
UniProt

2
CCDS

CCDS27773.1

Ensembl

ENSMUSG00000022451 (Evidence)
NCBI Gene

19230

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022451	Ensembl Gene Model \| MGI Sequence Detail	11939	C57BL/6J	± kb
transcript	ENSMUST00000023087	Ensembl \| MGI Sequence Detail	3025	Not Applicable
polypeptide	ENSMUSP00000023087	Ensembl \| MGI Sequence Detail	350	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016844 twinfilin-1

(term hierarchy)
PDB

1M4J, 2D8B, 2HD7, 3DAW, 6RSW, 6YP9, 7DS2, 7DS4, 7DS6, 7DS8, 7DSB
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR028458 Twinfilin

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 7

Summaries

All 66

Developmental Gene Expression 6

Diseases 1

Gene Ontology 10

Phenotypes 32
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:310143 Hakala M, et al., Twinfilin uncaps filament barbed ends to promote turnover of lamellipodial actin networks. Nat Cell Biol. 2021 Feb;23(2):147-159

TSS for Twf1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135995	Chr15:94487751-94487762 (-)	13 bp
Tssr135994	Chr15:94487713-94487745 (-)	41 bp
Tssr135993	Chr15:94487688-94487709 (-)	71 bp
Tssr135992	Chr15:94485965-94485968 (-)	1,803 bp
Tssr135991	Chr15:94485936-94485941 (-)	1,831 bp
Tssr135990	Chr15:94484391-94484412 (-)	3,368 bp
Tssr135989	Chr15:94477089-94477111 (-)	10,670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/27/2022 MGI 6.21