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Twf1
Gene Detail
 Symbol
Name
ID
Twf1
twinfilin, actin-binding protein, homolog 1 (Drosophila)
MGI:1100520
Synonyms A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
48.59 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:94577951-94589889 bp, - strand
From VEGA annotation of GRCm38

  11939 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: probable tyrosine kinase
Gene Tree: Twf1

Human
homologs
Human Homolog TWF1, twinfilin actin-binding protein 1
NCBI Gene ID 5756
neXtProt AC  NX_Q12792
Human Synonyms  A6, PTK9
Human Chr (Location)  12q12; chr12:43793723-43806375 (-)  GRCh38
Alleles
and
phenotypes
All alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process barbed-end actin filament capping, negative regulation of actin filament polymerization, ...
Component actin cytoskeleton, cell-cell junction, ...
Function actin binding, actin monomer binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (160)    Tissues (106)    Images (33)
Theiler Stages: 2, 3, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 124
RT-PCR 36
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000017538 (Evidence)
Ensembl Gene ModelENSMUSG00000022451 (Evidence)
Entrez Gene19230 (Evidence)
DFCITC1574306
DoTSDT.103587907, DT.91351675
PDB1M4J, 2D8B, 3DAW, 2HD7
Consensus CDS ProjectCCDS27773.1
International Mouse Knockout Project StatusTwf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017538 VEGA Gene Model | MGI Sequence Detail 11939 C57BL/6J ±  kb
transcript OTTMUST00000042612 VEGA | MGI Sequence Detail 3025 Not Applicable 
polypeptide OTTMUSP00000019148 VEGA | MGI Sequence Detail 350 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(107 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002108 Actin-binding, cofilin/tropomyosin type
Protein Ontology PR:000016844 twinfilin-1
References (Earliest) J:41824 Beeler JF, et al., Cloning and characterization of the mouse homolog of the human A6 gene. Gene. 1997 Jul 1;193(1):31-7
(Latest) J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory