Twf1 MGI Mouse Gene Detail - MGI:1100520 - twinfilin actin binding protein 1

Twf1 Gene Detail

Symbol

Twf1
Name

twinfilin actin binding protein 1
Synonyms

A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1

Feature Type

protein coding gene
IDs

MGI:1100520
NCBI Gene: 19230
Gene Overview

MyGene.info: TWF1
Alliance

gene page

Sequence Map

Chr15:94577951-94589889 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

11939 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 48.59 cM, cytoband F1
Mapping Data

2 experiments

Human Ortholog

TWF1, twinfilin actin binding protein 1

Vertebrate Orthologs

10

Human Ortholog

TWF1, twinfilin actin binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

A6, PTK9
Links

HGNC:9620

NCBI Gene ID: 5756

neXtProt AC: NX_Q12792

UniProt: Q12792
Chr Location

12q12; chr12:43793723-43806375 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48140
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TWF1
Protein SuperFamily

probable tyrosine kinase
Gene Tree

Twf1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
29 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Gene trapped

8
Radiation induced

2
Targeted

3
Genomic Mutations

3 involving Twf1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

31
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

160
Tissues

107
cDNA Data

17
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase twf1

ZFIN twf1a, twf1b

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Twf1 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

38
RefSeq

4
UniProt

2
CCDS

CCDS27773.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000017538	VEGA Gene Model \| MGI Sequence Detail	11939	C57BL/6J	± kb
transcript	OTTMUST00000042612	VEGA \| MGI Sequence Detail	3025	Not Applicable
polypeptide	OTTMUSP00000019148	VEGA \| MGI Sequence Detail	350	Not Applicable

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SNPs within 2kb

107 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000016844 twinfilin-1

(term hierarchy)
PDB

1M4J, 2D8B, 2HD7, 3DAW
InterPro Domains

IPR002108 Actin-depolymerising factor homology domain

IPR029006 ADF-H/Gelsolin-like domain superfamily

IPR028458 Twinfilin

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All nucleic 20

cDNA 18

Primer pair 2

Microarray probesets 7

Summaries

All 63

Developmental Gene Expression 6

Diseases 1

Gene Ontology 11

Phenotypes 29
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:247012 Stritt S, et al., Twinfilin 2a regulates platelet reactivity and turnover in mice. Blood. 2017 Oct 12;130(15):1746-1756

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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