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Twf1 Gene Detail
Summary
  • Symbol
    Twf1
  • Name
    twinfilin actin binding protein 1
  • Synonyms
    A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100520
    NCBI Gene: 19230
  • Gene Overview
    MyGene.info: TWF1
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:94577948-94589884 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 48.59 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100520
 protein coding gene Chr15:94577948-94589889 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022261
 protein coding gene Chr15:96049730-96061686 (-)
A/J MGP_AJ_G0022220
 protein coding gene Chr15:92312617-92324573 (-)
AKR/J MGP_AKRJ_G0022195
 protein coding gene Chr15:95102083-95114039 (-)
BALB/cJ MGP_BALBcJ_G0022226
 protein coding gene Chr15:92477160-92489093 (-)
C3H/HeJ MGP_C3HHeJ_G0021996
 protein coding gene Chr15:95119004-95130929 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022671
 protein coding gene Chr15:99566908-99579510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020197
 protein coding gene Chr15:88339602-88351717 (-)
CAST/EiJ MGP_CASTEiJ_G0021518
 protein coding gene Chr15:95935285-95947936 (-)
CBA/J MGP_CBAJ_G0021963
 protein coding gene Chr15:102919925-102932658 (-)
DBA/2J MGP_DBA2J_G0022090
 protein coding gene Chr15:91759007-91770962 (-)
FVB/NJ MGP_FVBNJ_G0022069
 protein coding gene Chr15:90762159-90774114 (-)
LP/J MGP_LPJ_G0022161
 protein coding gene Chr15:96167662-96179681 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022089
 protein coding gene Chr15:107214174-107227580 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022686
 protein coding gene Chr15:95185056-95197012 (-)
PWK/PhJ MGP_PWKPhJ_G0021259
 protein coding gene Chr15:91816068-91828586 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021093
 protein coding gene Chr15:94926846-94939164 (-)
WSB/EiJ MGP_WSBEiJ_G0021567
 protein coding gene Chr15:95688235-95700200 (-)



Homology
more
  • Human Ortholog
    TWF1, twinfilin actin binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TWF1, twinfilin actin binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A6, PTK9
  • Links
    NCBI Gene ID: 5756
    neXtProt AC: NX_Q12792
    UniProt: Q12792

  • Chr Location
    12q12; chr12:43793723-43806375 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    160
  • Tissues
    107
  • cDNA Data
    17
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19230 NCBI Gene Model | MGI Sequence Detail 11937 C57BL/6J ±  kb
    transcript NM_008971 RefSeq | MGI Sequence Detail 2973 C57BL/6  
    polypeptide Q91YR1 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 18
      Primer pair 2

      Microarray probesets 7
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 12
      Phenotypes 29
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:247012 Stritt S, et al., Twinfilin 2a regulates platelet reactivity and turnover in mice. Blood. 2017 Oct 12;130(15):1746-1756
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/04/2018
    MGI 6.13     		The Jackson Laboratory