Twf1
Gene Detail

Symbol Name ID

Twf1 twinfilin, actin-binding protein, homolog 1 (Drosophila) MGI:1100520

Synonyms

A6, actin monomer-binding protein, Ptk9, twinfilin, Twinfilin-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

48.59 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:94577951-94589889 bp, - strand From VEGA annotation of GRCm38   11939 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48140  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: probable tyrosine kinase
Gene Tree: Twf1

Human homologs

Human Homolog		TWF1, twinfilin actin-binding protein 1
NCBI Gene ID		5756
neXtProt AC		NX_Q12792
Human Synonyms		A6, PTK9
Human Chr (Location)		12q12; chr12:43793723-43806375 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(12) : Gene trapped(8) Radiation induced(1) Targeted(3)
Genomic Mutations involving Twf1 (1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Twf1 interacts with 261 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	barbed-end actin filament capping, negative regulation of actin filament polymerization, ...
Component	actin cytoskeleton, cell-cell junction, ...
Function	actin binding, actin monomer binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)

Data Summary: Results (160)    Tissues (106)    Images (33)
Theiler Stages: 2, 3, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	124
RT-PCR	36

cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000017538 (Evidence)
Ensembl Gene Model	ENSMUSG00000022451 (Evidence)
Entrez Gene	19230 (Evidence)
DFCI	TC1574306
DoTS	DT.103587907, DT.91351675
PDB	1M4J, 2D8B, 3DAW, 2HD7
Consensus CDS Project	CCDS27773.1
International Mouse Knockout Project Status	Twf1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017538	VEGA Gene Model | MGI Sequence Detail	11939	C57BL/6J
transcript	OTTMUST00000042612	VEGA | MGI Sequence Detail	3025	Not Applicable
polypeptide	OTTMUSP00000019148	VEGA | MGI Sequence Detail	350	Not Applicable

All sequences(41) RefSeq(4) UniProt(2)

Polymorphisms

SNPs within 2kb(107 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002108	Actin-binding, cofilin/tropomyosin type
Protein Ontology	PR:000016844	twinfilin-1

References

(Earliest) J:41824 Beeler JF, et al., Cloning and characterization of the mouse homolog of the human A6 gene. Gene. 1997 Jul 1;193(1):31-7
(Latest) J:201630 Ryder E, et al., Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mamm Genome. 2013 Aug;24(7-8):286-94
All references(41)