Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes TUBB4A
  • Mouse genes Tubb4a
  • Rat genes Tubb4a
  • Zfish genes tubb4bl,zgc:65894
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tubb4a

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	TUBB4A	IMP		Human	PMID:10211825
Molecular Function	GO:0005515	protein binding	TUBB4A	IPI	UniProtKB:P22736	Human	PMID:20195357
Molecular Function	GO:0005515	protein binding	TUBB4A	IPI	UniProtKB:Q5S007	Human	PMID:24275654
Molecular Function	GO:0005515	protein binding	TUBB4A	IPI	UniProtKB:Q5S007	Human	PMID:31046837
Cellular Component	GO:0005930	axoneme	TUBB4A	IDA		Human	PMID:12475942
Cellular Component	GO:0042995	cell projection	Tubb4a	IDA		Mouse	PMID:16421295
Cellular Component	GO:0005929	cilium	Tubb4a	IDA		Mouse	PMID:23284756
Cellular Component	GO:0005929	cilium	Tubb4a	IDA		Mouse	PMID:11724907
Cellular Component	GO:0005929	cilium	Tubb4a	IDA		Mouse	PMID:14625387
Cellular Component	GO:0005737	cytoplasm	Tubb4a	IDA		Mouse	PMID:16574095
Cellular Component	GO:0070062	extracellular exosome	TUBB4A	HDA		Human	PMID:23533145
Cellular Component	GO:0045171	intercellular bridge	TUBB4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0033269	internode region of axon	Tubb4a	IDA		Mouse	PMID:16421295
Cellular Component	GO:0005874	microtubule	TUBB4A	IDA		Human	PMID:21525035
Cellular Component	GO:0015630	microtubule cytoskeleton	TUBB4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0072686	mitotic spindle	TUBB4A	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043209	myelin sheath	Tubb4a	HDA		Mouse	MGI:MGI:3834050|PMID:17634366
Cellular Component	GO:0043209	myelin sheath	Tubb4a	IDA		Mouse	PMID:16421295
Cellular Component	GO:0043025	neuronal cell body	Tubb4a	IDA		Mouse	PMID:16421295
Cellular Component	GO:0005634	nucleus	TUBB4A	HDA		Human	PMID:21630459
Biological Process	GO:0031115	negative regulation of microtubule polymerization	TUBB4A	IMP		Human	PMID:10211825

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern